Cxcr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcr2
Entrez Gene ID	29385
Full Name	C-X-C motif chemokine receptor 2
Synonyms	Cmkar2,Il8rb
General protein information	Preferred Names C-X-C motif chemokine receptor 2 Names C-X-C chemokine receptor type 2 CXC-R2 CXCR-2 GRO/MGSA receptor IL-8R B chemokine (C-X-C motif) receptor 2 chemokine (C-X-C) receptor 2 high affinity interleukin-8 receptor B interleukin 8 receptor, beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33
Summary	chemokine receptor that binds Il8, GRO/MGSA and neutrophil activating peptide-2; involved in the inflammatory response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008767213.2	XP_008765435.1	C-X-C chemokine receptor type 2 isoform X1
NM_017183.1	NP_058879.1	C-X-C chemokine receptor type 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CXCR2	NP_001096131.1
Canis lupus familiaris (dog)	CXCR1	XP_005640697.1
Rattus norvegicus (Norway rat)	Cxcr2	NP_058879.1
Xenopus tropicalis (tropical clawed frog)	LOC101732165	XP_004917676.1
Canis lupus familiaris (dog)	CXCR2	NP_001003151.1
	IL8RB	XP_001088762.2
Bos taurus (cattle)	CXCR2	NP_776785.1
Mus musculus (house mouse)	Cxcr2	NP_034039.1
Danio rerio (zebrafish)	LOC796724	XP_001337093.2
Homo sapiens (human)	CXCR2	NP_001161770.1

Gene Ontology
Bibliography

Related articles in PubMed

Preclinical chorioamnionitis dysregulates CXCL1/CXCR2 signaling throughout the placental-fetal-brain axis.
Yellowhair TR, Noor S, Maxwell JR, Anstine CV, Oppong AY, Robinson S, Milligan ED, Jantzie LL
Experimental neurology(2017 Nov)

CXCR2 is involved in pulmonary intravascular macrophage accumulation and angiogenesis in a rat model of hepatopulmonary syndrome.
Li X, Chen Y, Chang Y, Li S, Zhao Z, Zhang H
Clinical science (London, England : 1979)131(2)159-168(2017 Jan)

Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats.
Yang LH, Xu GM, Wang Y
Neuroscience letters626135-41(2016 Jul)

Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion.
Zhou Y, Li RJ, Li M, Liu X, Zhu HY, Ju Z, Miao X, Xu GY
Molecular pain12(2016)

Effect of acupuncture on CXCL8 receptors in rats suffering from embryo implantation failure.
Gao WN, Yang W, Liu YF, Tang X, Guo Y, Wang LJ, Zhang MM, Huang GY
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban34(1)91-8(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The mRNA and protein levels of CXCR2 were significantly increased in the pulmonary tissue in a rat model of hepatopulmonary syndrome.
Title: CXCR2 is involved in pulmonary intravascular macrophage accumulation and angiogenesis in a rat model of hepatopulmonary syndrome.

Findings indicated that up-regulation of CXCL1 and CXCR2 might contribute to remifentanil-induce hypernociception via modulating spinal NR2B-containing NMDA receptor expression and phosphorylation in rats.
Title: Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats.

GRK6 might be a key molecular involved in peripheral mechanism of neuropathic pain and that overexpression of GRK6 might be a potential strategy for treatment for neuropathic pain through inhibition of CXCR2 signal pathway.
Title: Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion.

Findings indicate that acupuncture can increase the number of implanted embryos in embryo implantation failure, which may be relevant with up-regulation the expression of CXCL8 receptors CXCR1 and CXCR2 in endometrium.
Title: Effect of acupuncture on CXCL8 receptors in rats suffering from embryo implantation failure.

IL8RA-endothelial cells (EC), IL8RB-EC, and IL8RA/IL8RB-EC treatment reduces neointima formation dramatically in carotid artery endothelial cells at 28 days after injury.
Title: Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury.

The following Cxcr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13085	NM_017183.1 Latest version!	Rattus norvegicus C-X-C motif chemokine receptor 2 (Cxcr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa43262	XM_008767213.2 Latest version!	Rattus norvegicus C-X-C motif chemokine receptor 2 (Cxcr2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcr2 ( NM_017183.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058879.1 Rattus norvegicus C-X-C motif chemokine receptor 2 (Cxcr2), mRNA.

Price & Availability↑

CloneID	ORa13085
Clone ID Related Accession (Same CDS sequence)	NM_017183.1
Accession Version	NM_017183.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C chemokine receptor type 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X77797.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X77797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGGAGAAA TCAGGGTGGA TAATTTCAGC CTTGAAGACT TCTTCAGTGG AGATATTGAC 
AGTTACAATT ACAGTTCTGA CCCGCCCTTT ACTCTGTCAG ATGCTGCCCC ATGCCCCTCA 
GCGAACCTAG ATATCAACAG GTATGCTGTG GTTGTCATAT ACGTTCTGGT GACTTTGCTG 
AGTCTCGTGG GGAACTCCCT GGTGATGCTG GTCATCTTGT ACAATCGAAG CACCTGCTCT 
GTTACCGACG TCTACCTGCT GAACCTGGCC ATTGCTGATC TGTTCTTTGC CCTGACCTTG 
CCTGTCTGGG CTGCATCTAA AGTAAATGGA TGGATTTTTG GCTCATTCCT GTGCAAGGTA 
TTCTCGTTCC TGCAGGAGAT TACCTTCTAC AGCAGTGTTC TGTTGCTAGC CTGCATCAGC 
ATGGACCGCT ACCTGGCCAT CGTCCACGCC ACAAGTACAC TGATCCAGAA GAGACACTTG 
GTCAAGTTTG TGTGCATCAC CATGTGGTTT CTCTCACTAG TTCTGTCCCT GCCCATCTTC 
ATTCTTCGGA CTACTGTTAA GGCAAACCCT TCTACCGTAG TCTGCTATGA GAATATAGGT 
AATAATACAT CCAAGTGGAG GGTGGTACTG CGCATCCTGC CTCAGACCTA TGGCTTCCTC 
CTGCCGCTGC TCATCATGCT GTTCTGCTAT GGGTTCACAC TGCGCACGCT CTTTAAGGCC 
CACATGGGGC AGAAGCACCG GGCCATGCGG GTCATCTTTG CTGTGGTCCT CGTCTTCCTG 
CTCTGCTGGC TTCCCTACAA CATTGTCCTG TTCACAGACA CCCTCATGAG AACCAAGCTG 
ATCAAGGAGA CCTGTGAACG CCAGAACGAG ATTAACAAAG CTTTGGAAGC TACTGAGATT 
CTTGGCTTCC TCCACAGCTG TCTTAACCCC ATCATCTATG CCTTTATTGG CCAGAAATTT 
CGCCATGGAC TTCTCAAGAT CATGGCTAAT TATGGCCTTG TCAGCAAGGA GTTCTTAGCC 
AAGGAGGGCA GGCCTTCTTT TGTTGGCTCT TCTTCAGCGA ACACCTCCAC TACCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058879.1
CDS	132..1211
Translation	MGEIRVDNFSLEDFFSGDIDSYNYSSDPPFTLSDAAPCPSANLDINRYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWIFGSFLCKVFSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCITMWFLSLVLSLPIFILRTTVKANPSTVVCYENIGNNTSKWRVVLRILPQTYGFLLPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLMRTKLIKETCERQNEINKALEATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLVSKEFLAKEGRPSFVGSSSANTSTTL

Target ORF information:

RefSeq Version	NM_017183.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine receptor 2 (Cxcr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017183.1

ORF Insert Sequence:

ATGGGAGAAA TCAGGGTGGA TAATTTCAGC CTTGAAGACT TCTTCAGTGG AGATATTGAC 
AGTTACAATT ACAGTTCTGA CCCGCCCTTT ACTCTGTCAG ATGCTGCCCC ATGCCCCTCA 
GCGAACCTAG ATATCAACAG GTATGCTGTG GTTGTCATAT ACGTTCTGGT GACTTTGCTG 
AGTCTCGTGG GGAACTCCCT GGTGATGCTG GTCATCTTGT ACAATCGAAG CACCTGCTCT 
GTTACCGACG TCTACCTGCT GAACCTGGCC ATTGCTGATC TGTTCTTTGC CCTGACCTTG 
CCTGTCTGGG CTGCATCTAA AGTAAATGGA TGGATTTTTG GCTCATTCCT GTGCAAGGTA 
TTCTCGTTCC TGCAGGAGAT TACCTTCTAC AGCAGTGTTC TGTTGCTAGC CTGCATCAGC 
ATGGACCGCT ACCTGGCCAT CGTCCACGCC ACAAGTACAC TGATCCAGAA GAGACACTTG 
GTCAAGTTTG TGTGCATCAC CATGTGGTTT CTCTCACTAG TTCTGTCCCT GCCCATCTTC 
ATTCTTCGGA CTACTGTTAA GGCAAACCCT TCTACCGTAG TCTGCTATGA GAATATAGGT 
AATAATACAT CCAAGTGGAG GGTGGTACTG CGCATCCTGC CTCAGACCTA TGGCTTCCTC 
CTGCCGCTGC TCATCATGCT GTTCTGCTAT GGGTTCACAC TGCGCACGCT CTTTAAGGCC 
CACATGGGGC AGAAGCACCG GGCCATGCGG GTCATCTTTG CTGTGGTCCT CGTCTTCCTG 
CTCTGCTGGC TTCCCTACAA CATTGTCCTG TTCACAGACA CCCTCATGAG AACCAAGCTG 
ATCAAGGAGA CCTGTGAACG CCAGAACGAG ATTAACAAAG CTTTGGAAGC TACTGAGATT 
CTTGGCTTCC TCCACAGCTG TCTTAACCCC ATCATCTATG CCTTTATTGG CCAGAAATTT 
CGCCATGGAC TTCTCAAGAT CATGGCTAAT TATGGCCTTG TCAGCAAGGA GTTCTTAGCC 
AAGGAGGGCA GGCCTTCTTT TGTTGGCTCT TCTTCAGCGA ACACCTCCAC TACCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cxcr2 ( XM_008767213.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765435.1 Rattus norvegicus C-X-C motif chemokine receptor 2 (Cxcr2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43262
Clone ID Related Accession (Same CDS sequence)	XM_008767213.2
Accession Version	XM_008767213.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C chemokine receptor type 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767213.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGAAA TCAGGGTGGA TAATTTCAGC CTTGAAGACT TCTTCAGTGG AGATATTGAC 
AGTTACAATT ACAGTTCTGA CCCGCCCTTT ACTCTGTCAG ATGCTGCCCC ATGCCCCTCA 
GCGAACCTAG ATATCAACAG GTATGCTGTG GTTGTCATAT ACGTTCTGGT GACTTTGCTG 
AGTCTCGTGG GAAACTCCCT GGTGATGCTG GTCATCTTGT ACAATCGAAG CACCTGCTCT 
GTCACCGACG TCTACCTGCT GAACCTGGCC ATTGCTGATC TGTTCTTTGC CCTGACCTTG 
CCTGTCTGGG CTGCATCTAA AGTAAATGGA TGGATTTTTG GCTCATTCCT GTGCAAGGTA 
TTCTCGTTCC TGCAGGAGAT TACCTTCTAC AGCAGTGTTC TGTTGCTAGC CTGCATCAGC 
ATGGACCGCT ACCTGGCCAT CGTCCACGCC ACAAGTACAC TGATCCAGAA GAGACACTTG 
GTCAAGTTTG TGTGCATCAC CATGTGGTTT CTCTCACTAG TTCTGTCCCT GCCCATCTTC 
ATTCTTCGGA CTACTGTTAA GGCAAACCCT TCTACCGTAG TCTGCTATGA GAATATAGGT 
AATAATACAT CCAAGTGGAG GGTGGTACTG CGCATCCTGC CTCAGACCTA TGGCTTCCTC 
CTGCCGCTGC TCATCATGCT GTTCTGCTAT GGGTTCACAC TGCGCACGCT CTTTAAGGCC 
CACATGGGGC AGAAGCACCG GGCCATGCGG GTCATCTTTG CTGTGGTCCT CGTCTTCCTG 
CTCTGCTGGC TTCCCTACAA CATTGTCCTG TTCACAGACA CCCTCATGAG AACCAAGCTG 
ATCAAGGAGA CCTGTGAACG CCAGAACGAG ATTAACAAAG CTTTGGAAGC TACTGAGATT 
CTTGGCTTCC TCCACAGCTG TCTTAACCCC ATCATCTATG CCTTTATTGG CCAGAAATTT 
CGCCATGGAC TTCTCAAGAT CATGGCTAAT TATGGCCTTG TCAGCAAGGA GTTCTTAGCC 
AAGGAGGGCA GGCCTTCTTT TGTTGGCTCT TCTTCAGCGA ACACCTCCAC TACCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765435.1
CDS	459..1538
Translation	MGEIRVDNFSLEDFFSGDIDSYNYSSDPPFTLSDAAPCPSANLDINRYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWIFGSFLCKVFSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCITMWFLSLVLSLPIFILRTTVKANPSTVVCYENIGNNTSKWRVVLRILPQTYGFLLPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLMRTKLIKETCERQNEINKALEATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLVSKEFLAKEGRPSFVGSSSANTSTTL

Target ORF information:

RefSeq Version	XM_008767213.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine receptor 2 (Cxcr2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767213.2

ORF Insert Sequence:

ATGGGAGAAA TCAGGGTGGA TAATTTCAGC CTTGAAGACT TCTTCAGTGG AGATATTGAC 
AGTTACAATT ACAGTTCTGA CCCGCCCTTT ACTCTGTCAG ATGCTGCCCC ATGCCCCTCA 
GCGAACCTAG ATATCAACAG GTATGCTGTG GTTGTCATAT ACGTTCTGGT GACTTTGCTG 
AGTCTCGTGG GAAACTCCCT GGTGATGCTG GTCATCTTGT ACAATCGAAG CACCTGCTCT 
GTCACCGACG TCTACCTGCT GAACCTGGCC ATTGCTGATC TGTTCTTTGC CCTGACCTTG 
CCTGTCTGGG CTGCATCTAA AGTAAATGGA TGGATTTTTG GCTCATTCCT GTGCAAGGTA 
TTCTCGTTCC TGCAGGAGAT TACCTTCTAC AGCAGTGTTC TGTTGCTAGC CTGCATCAGC 
ATGGACCGCT ACCTGGCCAT CGTCCACGCC ACAAGTACAC TGATCCAGAA GAGACACTTG 
GTCAAGTTTG TGTGCATCAC CATGTGGTTT CTCTCACTAG TTCTGTCCCT GCCCATCTTC 
ATTCTTCGGA CTACTGTTAA GGCAAACCCT TCTACCGTAG TCTGCTATGA GAATATAGGT 
AATAATACAT CCAAGTGGAG GGTGGTACTG CGCATCCTGC CTCAGACCTA TGGCTTCCTC 
CTGCCGCTGC TCATCATGCT GTTCTGCTAT GGGTTCACAC TGCGCACGCT CTTTAAGGCC 
CACATGGGGC AGAAGCACCG GGCCATGCGG GTCATCTTTG CTGTGGTCCT CGTCTTCCTG 
CTCTGCTGGC TTCCCTACAA CATTGTCCTG TTCACAGACA CCCTCATGAG AACCAAGCTG 
ATCAAGGAGA CCTGTGAACG CCAGAACGAG ATTAACAAAG CTTTGGAAGC TACTGAGATT 
CTTGGCTTCC TCCACAGCTG TCTTAACCCC ATCATCTATG CCTTTATTGG CCAGAAATTT 
CGCCATGGAC TTCTCAAGAT CATGGCTAAT TATGGCCTTG TCAGCAAGGA GTTCTTAGCC 
AAGGAGGGCA GGCCTTCTTT TGTTGGCTCT TCTTCAGCGA ACACCTCCAC TACCCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Preclinical chorioamnionitis dysregulates CXCL1/CXCR2 signaling throughout the placental-fetal-brain axis.
Experimental neurology(2017 Nov)
Yellowhair TR,Noor S,Maxwell JR,Anstine CV,Oppong AY,Robinson S,Milligan ED,Jantzie LL

CXCR2 is involved in pulmonary intravascular macrophage accumulation and angiogenesis in a rat model of hepatopulmonary syndrome.
Clinical science (London, England : 1979)131(2)159-168(2017 Jan)
Li X,Chen Y,Chang Y,Li S,Zhao Z,Zhang H

Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats.
Neuroscience letters626135-41(2016 Jul)
Yang LH,Xu GM,Wang Y

Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion.
Molecular pain12(2016)
Zhou Y,Li RJ,Li M,Liu X,Zhu HY,Ju Z,Miao X,Xu GY

Effect of acupuncture on CXCL8 receptors in rats suffering from embryo implantation failure.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban34(1)91-8(2014 Feb)
Gao WN,Yang W,Liu YF,Tang X,Guo Y,Wang LJ,Zhang MM,Huang GY

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Cxcr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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