HSP90AA1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSP90AA1
Entrez Gene ID	281832
Full Name	heat shock protein 90 alpha family class A member 1
Synonyms	HSPCA
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012670.2	NP_001012688.1	heat shock protein HSP 90-alpha

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HSP90AA1	XP_005623992.1
Arabidopsis thaliana (thale cress)	HSP81-3	NP_200412.1
Arabidopsis thaliana (thale cress)	HSP81-2	NP_200414.1
Oryza sativa (rice)	Os09g0482100	NP_001063500.1
	HSP90AA1	XP_002805263.1
Arabidopsis thaliana (thale cress)	Hsp81.4	NP_200411.1
Oryza sativa (rice)	Os09g0482400	NP_001063503.1
Pan troglodytes (chimpanzee)	HSP90AA1	NP_001092042.1
Mus musculus (house mouse)	Hsp90aa1	NP_034610.1
Rattus norvegicus (Norway rat)	Hsp90aa1	NP_786937.1
Bos taurus (cattle)	HSP90AA1	NP_001012688.1
Gallus gallus (chicken)	HSP90AA1	NP_001103255.1
Oryza sativa (rice)	Os09g0482610	NP_001175894.1
Homo sapiens (human)	HSP90AA1	NP_001017963.2
Danio rerio (zebrafish)	hsp90aa1.2	NP_001038538.1
Danio rerio (zebrafish)	hsp90aa1.1	NP_571403.1
Xenopus tropicalis (tropical clawed frog)	hsp90aa1.1	NP_001016282.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic polymorphism in Hsp90AA1 gene is associated with the thermotolerance in Chinese Holstein cows.
Badri TM, Chen KL, Alsiddig MA, Li L, Cai Y, Wang GL
Cell stress & chaperones(2018 Jan)

Summer heat stress affects prostaglandin synthesis in the bovine oviduct.
Kobayashi Y, Wakamiya K, Kohka M, Yamamoto Y, Okuda K
Reproduction (Cambridge, England)146(2)103-10(2013 Aug)

Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.
Antonov AS, Antonova GN, Fujii M, ten Dijke P, Handa V, Catravas JD, Verin AD
Journal of cellular physiology227(2)759-71(2012 Feb)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex.
Okada M, Hatakeyama T, Itoh H, Tokuta N, Tokumitsu H, Kobayashi R
The Journal of biological chemistry279(6)4221-33(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of HSP90AA1 and PGES (prostaglandin-E synthase).
Title: Summer heat stress affects prostaglandin synthesis in the bovine oviduct.

This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 and ALK5 interact with heat shock protein 90(HSP90).
Title: Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.

The following HSP90AA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSP90AA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa44486	NM_001012670.2 Latest version!	Bos taurus heat shock protein 90 alpha family class A member 1 (HSP90AA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSP90AA1 ( NM_001012670.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001012688.1 Bos taurus heat shock protein 90 alpha family class A member 1 (HSP90AA1), mRNA.

Price & Availability↑

CloneID	OBa44486
Clone ID Related Accession (Same CDS sequence)	NM_001012670.2
Accession Version	NM_001012670.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2202bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Bos taurus(cattle)
Product	heat shock protein HSP 90-alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EV615064.1, AB072368.1 and EV698083.1. On Apr 28, 2011 this sequence version replaced NM_001012670.1. ##Evidence-Data-START## Transcript exon combination :: AB072368.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGCCCGAGG AGACCCAGGC CCAGGACCAG CCGATGGAGG AGGAGGAGGT GGAGACTTTC 
GCCTTCCAGG CGGAAATTGC CCAGTTGATG TCACTGATCA TCAACACTTT CTACTCGAAT 
AAGGAGATTT TTCTGAGGGA GCTGATTTCA AACTCGTCCG ACGCCCTGGA CAAGATCAGG 
TATGAGAGCT TGACCGATCC CAGTAAGTTA GATTCTGGGA AAGAGCTGCA CATTAATCTC 
ATACCGAACA AGCAAGATCG AACCCTCACC ATCGTGGACA CCGGCATTGG GATGACCAAG 
GCCGATTTGA TTAATAACCT GGGCACCATC GCCAAGTCCG GGACCAAAGC GTTCATGGAG 
GCTTTGCAGG CTGGCGCTGA TATCTCCATG ATTGGCCAGT TTGGTGTCGG GTTTTATTCA 
GCCTATTTGG TGGCTGAGAA AGTGACCGTC ATCACCAAAC ATAACGATGA TGAGCAGTAT 
GCCTGGGAGT CTTCTGCAGG AGGGTCCTTC ACAGTAAGGA CTGACACAGG AGAACCAATG 
GGACGTGGAA CAAAGGTTAT TCTGCATCTG AAAGAAGACC AGACTGAGTA CCTGGAGGAG 
CGGAGAATAA AGGAGATTGT GAAGAAGCAT TCTCAGTTCA TTGGCTATCC CATCACTCTT 
TTTGTGGAAA AGGAACGTGA TAAAGAAGTT AGTGATGATG AAGCAGAAGA GAAGGAAGAC 
AAAGAGGAAG AGAAGGAGAA AGAAGAAAAG GAGTCTGATG ACAAGCCCGA GATAGAAGAT 
GTTGGCTCAG ATGAAGAGGA GGAAGAGAAG AAGGACGGGG ACAAGAAGAA GAAAAAGAAG 
ATCAAGGAGA AGTACATCGA TCAAGAAGAG CTGAACAAGA CAAAGCCTAT CTGGACCAGA 
AACCCTGATG ACATCACTAA CGAGGAGTAT GGAGAGTTCT ACAAGAGCCT GACCAACGAT 
TGGGAGGATC ACTTGGCTGT CAAGCATTTT TCAGTTGAAG GACAGTTGGA ATTCAGAGCC 
CTTCTTTTTG TCCCAAGACG AGCTCCTTTT GACCTGTTTG AAAACAGAAA GAAGAAGAAC 
AACATTAAGT TGTATGTTCG CAGAGTATTC ATCATGGATA ACTGCGAGGA GCTAATCCCT 
GAATACCTGA ATTTCATTAG AGGTGTGGTG GATTCTGAGG ATCTTCCTCT GAACATTTCC 
CGTGAGATGT TGCAACAAAG CAAAATTTTG AAAGTTATCA GGAAGAATTT GGTCAAAAAG 
TGCTTGGAAC TCTTCACTGA ACTGGCAGAA GATAAGGAGA ACTACAAGAA GTTTTATGAG 
CAGTTCTCTA AAAATATTAA GCTTGGAATA CATGAAGATT CTCAAAATCG GAAGAAGCTT 
TCAGAGCTGT TGAGGTACTA TACTTCTGCT TCTGGTGATG AGATGGTTTC TCTCAAGGAC 
TATTGCACAA GAATGAAGGA AAACCAGAAA CACATCTATT ACATCACAGG TGAGACCAAG 
GACCAGGTGG CCAACTCGGC CTTCGTGGAG CGCCTCCGGA AGCACGGCTT GGAAGTGATC 
TACATGATCG AGCCCATTGA TGAGTACTGT GTGCAGCAGC TGAAGGAGTT TGAGGGGAAG 
ACCTTAGTGT CAGTCACCAA AGAGGGCCTG GAACTTCCAG AAGATGAGGA AGAGAAAAAG 
AAACAAGAAG AGAAAAAGAC AAAGTTTGAA AACCTCTGCA AAATCATGAA GGACATTTTG 
GAGAAGAAAG TTGAAAAGGT GGTTGTGTCA AACCGGTTGG TGACATCCCC ATGCTGCATT 
GTCACAAGCA CATACGGCTG GACAGCAAAC ATGGAACGGA TCATGAAGGC GCAAGCCCTG 
AGAGACAACT CCACGATGGG TTACATGGCT GCCAAGAAGC ACCTGGAGAT CAACCCTGAC 
CATTCCATCA TTGAGACCTT GAGGCAAAAG GCAGAGGCTG ACAAGAATGA CAAGTCTGTG 
AAGGATCTGG TCATCCTGCT GTACGAAACA GCTCTCCTGT CTTCTGGCTT CAGTCTGGAG 
GATCCCCAGA CACATGCCAA CAGGATCTAC AGGATGATCA AACTTGGTCT CGGTATTGAC 
GAGGATGACC CCACTGCTGA TGACAGCAGC GCCGCGGTCA CTGAGGAAAT GCCACCCCTG 
GAAGGAGACG ACGACACGTC CCGCATGGAG GAAGTGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012688.1
CDS	146..2347
Translation	MPEETQAQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDSSAAVTEEMPPLEGDDDTSRMEEVD

Target ORF information:

RefSeq Version	NM_001012670.2
Organism	Bos taurus(cattle)
Definition	Bos taurus heat shock protein 90 alpha family class A member 1 (HSP90AA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012670.2

ORF Insert Sequence:

ATGCCCGAGG AGACCCAGGC CCAGGACCAG CCGATGGAGG AGGAGGAGGT GGAGACTTTC 
GCCTTCCAGG CGGAAATTGC CCAGTTGATG TCACTGATCA TCAACACTTT CTACTCGAAT 
AAGGAGATTT TTCTGAGGGA GCTGATTTCA AACTCGTCCG ACGCCCTGGA CAAGATCAGG 
TATGAGAGCT TGACCGATCC CAGTAAGTTA GATTCTGGGA AAGAGCTGCA CATTAATCTC 
ATACCGAACA AGCAAGATCG AACCCTCACC ATCGTGGACA CCGGCATTGG GATGACCAAG 
GCCGATTTGA TTAATAACCT GGGCACCATC GCCAAGTCCG GGACCAAAGC GTTCATGGAG 
GCTTTGCAGG CTGGCGCTGA TATCTCCATG ATTGGCCAGT TTGGTGTCGG GTTTTATTCA 
GCCTATTTGG TGGCTGAGAA AGTGACCGTC ATCACCAAAC ATAACGATGA TGAGCAGTAT 
GCCTGGGAGT CTTCTGCAGG AGGGTCCTTC ACAGTAAGGA CTGACACAGG AGAACCAATG 
GGACGTGGAA CAAAGGTTAT TCTGCATCTG AAAGAAGACC AGACTGAGTA CCTGGAGGAG 
CGGAGAATAA AGGAGATTGT GAAGAAGCAT TCTCAGTTCA TTGGCTATCC CATCACTCTT 
TTTGTGGAAA AGGAACGTGA TAAAGAAGTT AGTGATGATG AAGCAGAAGA GAAGGAAGAC 
AAAGAGGAAG AGAAGGAGAA AGAAGAAAAG GAGTCTGATG ACAAGCCCGA GATAGAAGAT 
GTTGGCTCAG ATGAAGAGGA GGAAGAGAAG AAGGACGGGG ACAAGAAGAA GAAAAAGAAG 
ATCAAGGAGA AGTACATCGA TCAAGAAGAG CTGAACAAGA CAAAGCCTAT CTGGACCAGA 
AACCCTGATG ACATCACTAA CGAGGAGTAT GGAGAGTTCT ACAAGAGCCT GACCAACGAT 
TGGGAGGATC ACTTGGCTGT CAAGCATTTT TCAGTTGAAG GACAGTTGGA ATTCAGAGCC 
CTTCTTTTTG TCCCAAGACG AGCTCCTTTT GACCTGTTTG AAAACAGAAA GAAGAAGAAC 
AACATTAAGT TGTATGTTCG CAGAGTATTC ATCATGGATA ACTGCGAGGA GCTAATCCCT 
GAATACCTGA ATTTCATTAG AGGTGTGGTG GATTCTGAGG ATCTTCCTCT GAACATTTCC 
CGTGAGATGT TGCAACAAAG CAAAATTTTG AAAGTTATCA GGAAGAATTT GGTCAAAAAG 
TGCTTGGAAC TCTTCACTGA ACTGGCAGAA GATAAGGAGA ACTACAAGAA GTTTTATGAG 
CAGTTCTCTA AAAATATTAA GCTTGGAATA CATGAAGATT CTCAAAATCG GAAGAAGCTT 
TCAGAGCTGT TGAGGTACTA TACTTCTGCT TCTGGTGATG AGATGGTTTC TCTCAAGGAC 
TATTGCACAA GAATGAAGGA AAACCAGAAA CACATCTATT ACATCACAGG TGAGACCAAG 
GACCAGGTGG CCAACTCGGC CTTCGTGGAG CGCCTCCGGA AGCACGGCTT GGAAGTGATC 
TACATGATCG AGCCCATTGA TGAGTACTGT GTGCAGCAGC TGAAGGAGTT TGAGGGGAAG 
ACCTTAGTGT CAGTCACCAA AGAGGGCCTG GAACTTCCAG AAGATGAGGA AGAGAAAAAG 
AAACAAGAAG AGAAAAAGAC AAAGTTTGAA AACCTCTGCA AAATCATGAA GGACATTTTG 
GAGAAGAAAG TTGAAAAGGT GGTTGTGTCA AACCGGTTGG TGACATCCCC ATGCTGCATT 
GTCACAAGCA CATACGGCTG GACAGCAAAC ATGGAACGGA TCATGAAGGC GCAAGCCCTG 
AGAGACAACT CCACGATGGG TTACATGGCT GCCAAGAAGC ACCTGGAGAT CAACCCTGAC 
CATTCCATCA TTGAGACCTT GAGGCAAAAG GCAGAGGCTG ACAAGAATGA CAAGTCTGTG 
AAGGATCTGG TCATCCTGCT GTACGAAACA GCTCTCCTGT CTTCTGGCTT CAGTCTGGAG 
GATCCCCAGA CACATGCCAA CAGGATCTAC AGGATGATCA AACTTGGTCT CGGTATTGAC 
GAGGATGACC CCACTGCTGA TGACAGCAGC GCCGCGGTCA CTGAGGAAAT GCCACCCCTG 
GAAGGAGACG ACGACACGTC CCGCATGGAG GAAGTGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic polymorphism in Hsp90AA1 gene is associated with the thermotolerance in Chinese Holstein cows.
Cell stress & chaperones(2018 Jan)
Badri TM,Chen KL,Alsiddig MA,Li L,Cai Y,Wang GL

Summer heat stress affects prostaglandin synthesis in the bovine oviduct.
Reproduction (Cambridge, England)146(2)103-10(2013 Aug)
Kobayashi Y,Wakamiya K,Kohka M,Yamamoto Y,Okuda K

Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.
Journal of cellular physiology227(2)759-71(2012 Feb)
Antonov AS,Antonova GN,Fujii M,ten Dijke P,Handa V,Catravas JD,Verin AD

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex.
The Journal of biological chemistry279(6)4221-33(2004 Feb)
Okada M,Hatakeyama T,Itoh H,Tokuta N,Tokumitsu H,Kobayashi R

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HSP90AA1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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