ORC5 cDNA ORF clone, Arabidopsis thaliana(thale cress)

The following ORC5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORC5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OAb16705 NM_119137.5
Latest version!
Arabidopsis thaliana origin recognition complex protein 5 (ORC5), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $342.30
$489.00
OAb39865 NM_001341981.1
Latest version!
Arabidopsis thaliana origin recognition complex protein 5 (ORC5), mRNA. pcDNA3.1-C-(k)DYK or customized vector 14-16 $342.30
$489.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

  • Reference Sequences (Refseq)
    CloneID OAb16705
    Clone ID Related Accession (Same CDS sequence) NM_119137.5
    Accession Version NM_119137.5 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1605bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product origin recognition complex protein 5
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075). On Sep 12, 2016 this sequence version replaced NM_119137.4.

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGCCTCCTA AAGAGGAGAG TTCGAAAGTC ACTCGAAGAA GCACTAGGTC ATCAGCTTCT 
    GTAACTGTTG AGAACTCAGA ACCTATTGAA TCCCACACAC CAACCATTGA TGATCTCACA
    TTTGGGGAAG AATCAATCAC AATTGATGCT GTTCTATCTA ATTTTCCAGG CAGACGCTCT
    CAGATTTTCG ACTTTATTCG ACTTATGGGG CCGTTAGATT GCCCTACTCT TCCAATAATG
    ATCTATGGAG GTGCTTCTAC GGGAAAAACC AGTGTTGTTC TTCAGGTGCT CAGGCATCTC
    AATCGTCCCT TTGTTTATTC AAGCTGTCGT ACGTGTTACA ATCCCCGTAT CTTGTTTGAG
    TCGATTCTGA ATCAGTCGTT GCTACATAGG AAGTGTTCTT TAAACGGGTA TTCTAGTGCG
    AAACGATGTG ACAAGCCATC TGATTTTGTC AACTTGCTTC GTGAAGCCCT TAGTAGTGTG
    ATAAAGACTC TCGAGTCTAC TTCCGAAACC TCAAGATCAG ATAAGCCGGA TGAAAAACCC
    ATGGGGAAGA TGGTGTACTT AATACTTGAT AATGTGGATC TTATCAGAGA CTGGGATAAA
    GGCACCATCA TTCTGCAGTT TCTTTTCAGT TTGTATACTG TTTTGAAGAT GCCTCAACTT
    GGTATAATAC TTATCAGTGG TTTGCCACCA GATGTGTATT ACTCAAACAT GGGATACACA
    GATCCTATAC CTCTTTATTT TCCTGAGTAT TCTGAAGAGG ATCTTCGTCA AATTTTCTTG
    AGAAATCAAC CTAACCGAAA ATTGTACTCT GCATTCCTTG ACGTTGTGTT GAAACCATTC
    TGTAGAGTCA CCAGGAGAGT TGAGGAACTG TCTACTACCT TCTCATTATT GTTCAGAAAG
    TTTTGTGAGC CACTTGATGA TTTAGGGATT TCACCAAATG AAGACATGAA GAGAAGGCTA
    TATAGCCATC TTAAGCCGCT TATTGCTCAT TGTTTAAATG AGATATTCAG GGTCTCTAGT
    CACCCTCATG ATGGCGAAAC CAGAGGCGAG AGAAGGCAGA AAGCCAGCTA CAGTTCTGAA
    AACCGTGAAG AACTTGAAAT ATTGGACTTC CATATGTCTA CTTCAGCAAA GTTTCTTCTT
    CTTTCGGCAT TTCTCGCTTC GAGAAACCCA GCAACGCTAG ACGCGTCAAT GTTTGACTCC
    ACAGGGGGAA TGGATAATCG TAAAAGAAAG CGGAAGGCCT CTGAGAAATC AATGGAAAAG
    AAGGAAATTG CAGAGCAGGA AGCAGTCATG AAAGGACCTG GAAGCTTTCC ACTGGAAAGA
    CTATTGGCGA TATTCCAATG TATTGCCTCC GTTGGAGATT CTTCATTTGG CGAAGAGGAC
    GAAGAAGAAG AAAACACAAC GGGTTACGAC AAAGAGAATA ACAATCTGAT GTCTGATATT
    CTGCTGCAAG TGTCAAGTCT ATGTGATGCT AACTTTTTAA TCAAAAGCGG AAGCTGCCCA
    TTAGAAGGTT CTATTAGGTA CCGTTCTATG GTCTCTGAAG ATCTGGCTCA GAAGGTTGCA
    AAAAGTCTTA GCTTTCCACT ATCCAAATAC TTGTACAGAA GATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_194720.2
    CDS133..1737
    Translation

    Target ORF information:

    RefSeq Version NM_119137.5
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana origin recognition complex protein 5 (ORC5), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_119137.5

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGCCTCCTA AAGAGGAGAG TTCGAAAGTC ACTCGAAGAA GCACTAGGTC ATCAGCTTCT 
    GTAACTGTTG AGAACTCAGA ACCTATTGAA TCCCACACAC CAACCATTGA TGATCTCACA
    TTTGGGGAAG AATCAATCAC AATTGATGCT GTTCTATCTA ATTTTCCAGG CAGACGCTCT
    CAGATTTTCG ACTTTATTCG ACTTATGGGG CCGTTAGATT GCCCTACTCT TCCAATAATG
    ATCTATGGAG GTGCTTCTAC GGGAAAAACC AGTGTTGTTC TTCAGGTGCT CAGGCATCTC
    AATCGTCCCT TTGTTTATTC AAGCTGTCGT ACGTGTTACA ATCCCCGTAT CTTGTTTGAG
    TCGATTCTGA ATCAGTCGTT GCTACATAGG AAGTGTTCTT TAAACGGGTA TTCTAGTGCG
    AAACGATGTG ACAAGCCATC TGATTTTGTC AACTTGCTTC GTGAAGCCCT TAGTAGTGTG
    ATAAAGACTC TCGAGTCTAC TTCCGAAACC TCAAGATCAG ATAAGCCGGA TGAAAAACCC
    ATGGGGAAGA TGGTGTACTT AATACTTGAT AATGTGGATC TTATCAGAGA CTGGGATAAA
    GGCACCATCA TTCTGCAGTT TCTTTTCAGT TTGTATACTG TTTTGAAGAT GCCTCAACTT
    GGTATAATAC TTATCAGTGG TTTGCCACCA GATGTGTATT ACTCAAACAT GGGATACACA
    GATCCTATAC CTCTTTATTT TCCTGAGTAT TCTGAAGAGG ATCTTCGTCA AATTTTCTTG
    AGAAATCAAC CTAACCGAAA ATTGTACTCT GCATTCCTTG ACGTTGTGTT GAAACCATTC
    TGTAGAGTCA CCAGGAGAGT TGAGGAACTG TCTACTACCT TCTCATTATT GTTCAGAAAG
    TTTTGTGAGC CACTTGATGA TTTAGGGATT TCACCAAATG AAGACATGAA GAGAAGGCTA
    TATAGCCATC TTAAGCCGCT TATTGCTCAT TGTTTAAATG AGATATTCAG GGTCTCTAGT
    CACCCTCATG ATGGCGAAAC CAGAGGCGAG AGAAGGCAGA AAGCCAGCTA CAGTTCTGAA
    AACCGTGAAG AACTTGAAAT ATTGGACTTC CATATGTCTA CTTCAGCAAA GTTTCTTCTT
    CTTTCGGCAT TTCTCGCTTC GAGAAACCCA GCAACGCTAG ACGCGTCAAT GTTTGACTCC
    ACAGGGGGAA TGGATAATCG TAAAAGAAAG CGGAAGGCCT CTGAGAAATC AATGGAAAAG
    AAGGAAATTG CAGAGCAGGA AGCAGTCATG AAAGGACCTG GAAGCTTTCC ACTGGAAAGA
    CTATTGGCGA TATTCCAATG TATTGCCTCC GTTGGAGATT CTTCATTTGG CGAAGAGGAC
    GAAGAAGAAG AAAACACAAC GGGTTACGAC AAAGAGAATA ACAATCTGAT GTCTGATATT
    CTGCTGCAAG TGTCAAGTCT ATGTGATGCT AACTTTTTAA TCAAAAGCGG AAGCTGCCCA
    TTAGAAGGTT CTATTAGGTA CCGTTCTATG GTCTCTGAAG ATCTGGCTCA GAAGGTTGCA
    AAAAGTCTTA GCTTTCCACT ATCCAAATAC TTGTACAGAA GATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OAb39865
    Clone ID Related Accession (Same CDS sequence) NM_001341981.1
    Accession Version NM_001341981.1 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1695bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product origin recognition complex protein 5
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075).

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGTTTCACC TACTTGAATT CCCAAATCTA AATCATCCTT TATTGTTTTC ACCAATGTCT 
    TGTTTCATTT TGACACAAGG TTTTAAGAAC ATGCCTCCTA AAGAGGAGAG TTCGAAAGTC
    ACTCGAAGAA GCACTAGGTC ATCAGCTTCT GTAACTGTTG AGAACTCAGA ACCTATTGAA
    TCCCACACAC CAACCATTGA TGATCTCACA TTTGGGGAAG AATCAATCAC AATTGATGCT
    GTTCTATCTA ATTTTCCAGG CAGACGCTCT CAGATTTTCG ACTTTATTCG ACTTATGGGG
    CCGTTAGATT GCCCTACTCT TCCAATAATG ATCTATGGAG GTGCTTCTAC GGGAAAAACC
    AGTGTTGTTC TTCAGGTGCT CAGGCATCTC AATCGTCCCT TTGTTTATTC AAGCTGTCGT
    ACGTGTTACA ATCCCCGTAT CTTGTTTGAG TCGATTCTGA ATCAGTCGTT GCTACATAGG
    AAGTGTTCTT TAAACGGGTA TTCTAGTGCG AAACGATGTG ACAAGCCATC TGATTTTGTC
    AACTTGCTTC GTGAAGCCCT TAGTAGTGTG ATAAAGACTC TCGAGTCTAC TTCCGAAACC
    TCAAGATCAG ATAAGCCGGA TGAAAAACCC ATGGGGAAGA TGGTGTACTT AATACTTGAT
    AATGTGGATC TTATCAGAGA CTGGGATAAA GGCACCATCA TTCTGCAGTT TCTTTTCAGT
    TTGTATACTG TTTTGAAGAT GCCTCAACTT GGTATAATAC TTATCAGTGG TTTGCCACCA
    GATGTGTATT ACTCAAACAT GGGATACACA GATCCTATAC CTCTTTATTT TCCTGAGTAT
    TCTGAAGAGG ATCTTCGTCA AATTTTCTTG AGAAATCAAC CTAACCGAAA ATTGTACTCT
    GCATTCCTTG ACGTTGTGTT GAAACCATTC TGTAGAGTCA CCAGGAGAGT TGAGGAACTG
    TCTACTACCT TCTCATTATT GTTCAGAAAG TTTTGTGAGC CACTTGATGA TTTAGGGATT
    TCACCAAATG AAGACATGAA GAGAAGGCTA TATAGCCATC TTAAGCCGCT TATTGCTCAT
    TGTTTAAATG AGATATTCAG GGTCTCTAGT CACCCTCATG ATGGCGAAAC CAGAGGCGAG
    AGAAGGCAGA AAGCCAGCTA CAGTTCTGAA AACCGTGAAG AACTTGAAAT ATTGGACTTC
    CATATGTCTA CTTCAGCAAA GTTTCTTCTT CTTTCGGCAT TTCTCGCTTC GAGAAACCCA
    GCAACGCTAG ACGCGTCAAT GTTTGACTCC ACAGGGGGAA TGGATAATCG TAAAAGAAAG
    CGGAAGGCCT CTGAGAAATC AATGGAAAAG AAGGAAATTG CAGAGCAGGA AGCAGTCATG
    AAAGGACCTG GAAGCTTTCC ACTGGAAAGA CTATTGGCGA TATTCCAATG TATTGCCTCC
    GTTGGAGATT CTTCATTTGG CGAAGAGGAC GAAGAAGAAG AAAACACAAC GGGTTACGAC
    AAAGAGAATA ACAATCTGAT GTCTGATATT CTGCTGCAAG TGTCAAGTCT ATGTGATGCT
    AACTTTTTAA TCAAAAGCGG AAGCTGCCCA TTAGAAGGTT CTATTAGGTA CCGTTCTATG
    GTCTCTGAAG ATCTGGCTCA GAAGGTTGCA AAAAGTCTTA GCTTTCCACT ATCCAAATAC
    TTGTACAGAA GATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_001328994.1
    CDS660..2354
    Translation

    Target ORF information:

    RefSeq Version NM_001341981.1
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana origin recognition complex protein 5 (ORC5), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_001341981.1

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGTTTCACC TACTTGAATT CCCAAATCTA AATCATCCTT TATTGTTTTC ACCAATGTCT 
    TGTTTCATTT TGACACAAGG TTTTAAGAAC ATGCCTCCTA AAGAGGAGAG TTCGAAAGTC
    ACTCGAAGAA GCACTAGGTC ATCAGCTTCT GTAACTGTTG AGAACTCAGA ACCTATTGAA
    TCCCACACAC CAACCATTGA TGATCTCACA TTTGGGGAAG AATCAATCAC AATTGATGCT
    GTTCTATCTA ATTTTCCAGG CAGACGCTCT CAGATTTTCG ACTTTATTCG ACTTATGGGG
    CCGTTAGATT GCCCTACTCT TCCAATAATG ATCTATGGAG GTGCTTCTAC GGGAAAAACC
    AGTGTTGTTC TTCAGGTGCT CAGGCATCTC AATCGTCCCT TTGTTTATTC AAGCTGTCGT
    ACGTGTTACA ATCCCCGTAT CTTGTTTGAG TCGATTCTGA ATCAGTCGTT GCTACATAGG
    AAGTGTTCTT TAAACGGGTA TTCTAGTGCG AAACGATGTG ACAAGCCATC TGATTTTGTC
    AACTTGCTTC GTGAAGCCCT TAGTAGTGTG ATAAAGACTC TCGAGTCTAC TTCCGAAACC
    TCAAGATCAG ATAAGCCGGA TGAAAAACCC ATGGGGAAGA TGGTGTACTT AATACTTGAT
    AATGTGGATC TTATCAGAGA CTGGGATAAA GGCACCATCA TTCTGCAGTT TCTTTTCAGT
    TTGTATACTG TTTTGAAGAT GCCTCAACTT GGTATAATAC TTATCAGTGG TTTGCCACCA
    GATGTGTATT ACTCAAACAT GGGATACACA GATCCTATAC CTCTTTATTT TCCTGAGTAT
    TCTGAAGAGG ATCTTCGTCA AATTTTCTTG AGAAATCAAC CTAACCGAAA ATTGTACTCT
    GCATTCCTTG ACGTTGTGTT GAAACCATTC TGTAGAGTCA CCAGGAGAGT TGAGGAACTG
    TCTACTACCT TCTCATTATT GTTCAGAAAG TTTTGTGAGC CACTTGATGA TTTAGGGATT
    TCACCAAATG AAGACATGAA GAGAAGGCTA TATAGCCATC TTAAGCCGCT TATTGCTCAT
    TGTTTAAATG AGATATTCAG GGTCTCTAGT CACCCTCATG ATGGCGAAAC CAGAGGCGAG
    AGAAGGCAGA AAGCCAGCTA CAGTTCTGAA AACCGTGAAG AACTTGAAAT ATTGGACTTC
    CATATGTCTA CTTCAGCAAA GTTTCTTCTT CTTTCGGCAT TTCTCGCTTC GAGAAACCCA
    GCAACGCTAG ACGCGTCAAT GTTTGACTCC ACAGGGGGAA TGGATAATCG TAAAAGAAAG
    CGGAAGGCCT CTGAGAAATC AATGGAAAAG AAGGAAATTG CAGAGCAGGA AGCAGTCATG
    AAAGGACCTG GAAGCTTTCC ACTGGAAAGA CTATTGGCGA TATTCCAATG TATTGCCTCC
    GTTGGAGATT CTTCATTTGG CGAAGAGGAC GAAGAAGAAG AAAACACAAC GGGTTACGAC
    AAAGAGAATA ACAATCTGAT GTCTGATATT CTGCTGCAAG TGTCAAGTCT ATGTGATGCT
    AACTTTTTAA TCAAAAGCGG AAGCTGCCCA TTAGAAGGTT CTATTAGGTA CCGTTCTATG
    GTCTCTGAAG ATCTGGCTCA GAAGGTTGCA AAAAGTCTTA GCTTTCCACT ATCCAAATAC
    TTGTACAGAA GATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

  • PubMed

    Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.
    Nature402(6763)769-77(1999 Dec)
    Mayer K,Sch?ller C,Wambutt R,Murphy G,Volckaert G,Pohl T,D?sterh?ft A,Stiekema W,Entian KD,Terryn N,Harris B,Ansorge W,Brandt P,Grivell L,Rieger M,Weichselgartner M,de Simone V,Obermaier B,Mache R,M?ller M,Kreis M,Delseny M,Puigdomenech P,Watson M,Schmidtheini T,Reichert B,Portatelle D,Perez-Alonso M,Boutry M,Bancroft I,Vos P,Hoheisel J,Zimmermann W,Wedler H,Ridley P,Langham SA,McCullagh B,Bilham L,Robben J,Van der Schueren J,Grymonprez B,Chuang YJ,Vandenbussche F,Braeken M,Weltjens I,Voet M,Bastiaens I,Aert R,Defoor E,Weitzenegger T,Bothe G,Ramsperger U,Hilbert H,Braun M,Holzer E,Brandt A,Peters S,van Staveren M,Dirske W,Mooijman P,Klein Lankhorst R,Rose M,Hauf J,K?tter P,Berneiser S,Hempel S,Feldpausch M,Lamberth S,Van den Daele H,De Keyser A,Buysshaert C,Gielen J,Villarroel R,De Clercq R,Van Montagu M,Rogers J,Cronin A,Quail M,Bray-Allen S,Clark L,Doggett J,Hall S,Kay M,Lennard N,McLay K,Mayes R,Pettett A,Rajandream MA,Lyne M,Benes V,Rechmann S,Borkova D,Bl?cker H,Scharfe M,Grimm M,L?hnert TH,Dose S,de Haan M,Maarse A,Sch?fer M,M?ller-Auer S,Gabel C,Fuchs M,Fartmann B,Granderath K,Dauner D,Herzl A,Neumann S,Argiriou A,Vitale D,Liguori R,Piravandi E,Massenet O,Quigley F,Clabauld G,M?ndlein A,Felber R,Schnabl S,Hiller R,Schmidt W,Lecharny A,Aubourg S,Chefdor F,Cooke R,Berger C,Montfort A,Casacuberta E,Gibbons T,Weber N,Vandenbol M,Bargues M,Terol J,Torres A,Perez-Perez A,Purnelle B,Bent E,Johnson S,Tacon D,Jesse T,Heijnen L,Schwarz S,Scholler P,Heber S,Francs P,Bielke C,Frishman D,Haase D,Lemcke K,Mewes HW,Stocker S,Zaccaria P,Bevan M,Wilson RK,de la Bastide M,Habermann K,Parnell L,Dedhia N,Gnoj L,Schutz K,Huang E,Spiegel L,Sehkon M,Murray J,Sheet P,Cordes M,Abu-Threideh J,Stoneking T,Kalicki J,Graves T,Harmon G,Edwards J,Latreille P,Courtney L,Cloud J,Abbott A,Scott K,Johnson D,Minx P,Bentley D,Fulton B,Miller N,Greco T,Kemp K,Kramer J,Fulton L,Mardis E,Dante M,Pepin K,Hillier L,Nelson J,Spieth J,Ryan E,Andrews S,Geisel C,Layman D,Du H,Ali J,Berghoff A,Jones K,Drone K,Cotton M,Joshu C,Antonoiu B,Zidanic M,Strong C,Sun H,Lamar B,Yordan C,Ma P,Zhong J,Preston R,Vil D,Shekher M,Matero A,Shah R,Swaby IK,O'Shaughnessy A,Rodriguez M,Hoffmann J,Till S,Granat S,Shohdy N,Hasegawa A,Hameed A,Lodhi M,Johnson A,Chen E,Marra M,Martienssen R,McCombie WR