AT4G12670 cDNA ORF clone, Arabidopsis thaliana(thale cress)

The following AT4G12670 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AT4G12670 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OAb14747 NM_117336.3
Latest version!
Arabidopsis thaliana Homeodomain-like superfamily protein (AT4G12670), partial mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $223.30
$319.00
OAb39188 NM_001340797.1
Latest version!
Arabidopsis thaliana Homeodomain-like superfamily protein (AT4G12670), mRNA. pcDNA3.1-C-(k)DYK or customized vector 14-16 $307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

  • Reference Sequences (Refseq)
    CloneID OAb14747
    Clone ID Related Accession (Same CDS sequence) NM_117336.3
    Accession Version NM_117336.3 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1500bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product Homeodomain-like superfamily protein
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075). On Apr 24, 2008 this sequence version replaced NM_117336.2. COMPLETENESS: incomplete on the 3' end.

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGCTGACTG ACAAGTCTAG GAAGGGATGT AGAGAGAGTT TAGGAGGAGT AGATGTGGGT 
    TTAATGATGG AGAAAGAAGC TGGAGGTGTT GAGAATGTAG TGGAGGTTAA TGTTTCTGGA
    GCAAGTGGTA TGGTTAGTGG GAAGAGAAGG GAAGGTGATG GATTAAACAA TAAATGGATA
    GTGATCGAGA AGAGTCAGAA AATGCAAAAA GTTGCTGCTG AAACTCATTC TCGGGAAAAT
    TCTAAGGCTG ATGATATTGA TTCGGATAAG GGAAGAAAGC AGCGAGGAAG ATTTAATGAG
    AAGAATTATG AAATTTCATA TGCGTGCATT TCTAATGCAG GTGAGGGAAG AAAGGGAAGG
    GTAAGAAGAG GTAATGAGAA AAATCATCAA GCACCAGAAG CGCACAGTAT TGATGTTGGT
    GGGGAAAGAA AGCGACAGAG AAGATGCGAT GATATAAACC ATGAAAAAGC ACAACCGCAC
    AGTTTTGCTG TTGGTATCAA AACAAAAGAG AAGAGGAGAT ACAGTGAGAA GAACCAGCAA
    AACAAAACAG TTGCAACTAC TCATGAACAC GACGTCTTAA CTAATGATGG AAGAACAGAA
    GCCCGCGATT CTGATTTCGG TGAGGGAAGA AGTGGGCAAG GATGTTTCCA TGAGAATAAC
    CAGCAAACGA AAGTGTCGTC TACTGAAAGA TGCGAGCAGG AAATCCCTAG GACCAATAAA
    AGAGTGTCAC TCGGTTCTGG ATTAGGGGAG GGGCGATATC GGGAGGGAAG ACATATTGAA
    AAGAATCAGC ATACCGAAAC TGTTAAAACT GAAACTCATG GGAAGGAAGT TTCTAAGGAT
    AGGAAGAGAA AGCGGGAAAG AGGAGTGGAA AGAGATGGGG ATGAGTTCTA TTTGGCGGAG
    AATCAAGACA GACAATGCCA AGCTGATATG AGAAATGATG ATGTGGCCTT CAATAAGCAA
    GCGACTGGTT TCAGCACAGT TGAACAAGTA GAGCGAAAGT CTGTATCATC TATTTCATCT
    CCGGAGTCTA CAAACAATGT TAACGACCCT AATGTTGCTT TTCAAGAGTT AGCTTTGATC
    ATCCACCCTA AGGCTGGTGT ACAAGAACAA CCTATCGAAG CACGACCTTT ACGCTCTGTC
    TCTTCGAAGA AACCATCTTT TCAACCTGAA AAATACGGAC ACAAAAGTTA CCTGGAGAAG
    AATGGACCTG CGTCTAATGA TCCCGCACAA AGTGCTACAA AAAGGAAAAG ACGATTTTGG
    ACGCTGGCAG AAGTAGAGAT GCTTAGGGTT GGTGTGCAGA AATTCCCTGG CGAGAGGAAT
    ATTCCATGGC GCAAAATCTT GCAATTTGGT CGGGATGTGT TTCATGATGA ACGGGCTCCA
    AGCGACCTCA AGGACAAGTG GAAGACGTTA AACAAAATTC CTTCTGACAC GGGGAAATGG
    GTAAGCCTTT CAACTGAAAG ACAACCGAAT TACTATGTGT CTGAAGTTAG TTCTGAATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_193003.2
    CDS330..1829
    Translation

    Target ORF information:

    RefSeq Version NM_117336.3
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana Homeodomain-like superfamily protein (AT4G12670), partial mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_117336.3

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGCTGACTG ACAAGTCTAG GAAGGGATGT AGAGAGAGTT TAGGAGGAGT AGATGTGGGT 
    TTAATGATGG AGAAAGAAGC TGGAGGTGTT GAGAATGTAG TGGAGGTTAA TGTTTCTGGA
    GCAAGTGGTA TGGTTAGTGG GAAGAGAAGG GAAGGTGATG GATTAAACAA TAAATGGATA
    GTGATCGAGA AGAGTCAGAA AATGCAAAAA GTTGCTGCTG AAACTCATTC TCGGGAAAAT
    TCTAAGGCTG ATGATATTGA TTCGGATAAG GGAAGAAAGC AGCGAGGAAG ATTTAATGAG
    AAGAATTATG AAATTTCATA TGCGTGCATT TCTAATGCAG GTGAGGGAAG AAAGGGAAGG
    GTAAGAAGAG GTAATGAGAA AAATCATCAA GCACCAGAAG CGCACAGTAT TGATGTTGGT
    GGGGAAAGAA AGCGACAGAG AAGATGCGAT GATATAAACC ATGAAAAAGC ACAACCGCAC
    AGTTTTGCTG TTGGTATCAA AACAAAAGAG AAGAGGAGAT ACAGTGAGAA GAACCAGCAA
    AACAAAACAG TTGCAACTAC TCATGAACAC GACGTCTTAA CTAATGATGG AAGAACAGAA
    GCCCGCGATT CTGATTTCGG TGAGGGAAGA AGTGGGCAAG GATGTTTCCA TGAGAATAAC
    CAGCAAACGA AAGTGTCGTC TACTGAAAGA TGCGAGCAGG AAATCCCTAG GACCAATAAA
    AGAGTGTCAC TCGGTTCTGG ATTAGGGGAG GGGCGATATC GGGAGGGAAG ACATATTGAA
    AAGAATCAGC ATACCGAAAC TGTTAAAACT GAAACTCATG GGAAGGAAGT TTCTAAGGAT
    AGGAAGAGAA AGCGGGAAAG AGGAGTGGAA AGAGATGGGG ATGAGTTCTA TTTGGCGGAG
    AATCAAGACA GACAATGCCA AGCTGATATG AGAAATGATG ATGTGGCCTT CAATAAGCAA
    GCGACTGGTT TCAGCACAGT TGAACAAGTA GAGCGAAAGT CTGTATCATC TATTTCATCT
    CCGGAGTCTA CAAACAATGT TAACGACCCT AATGTTGCTT TTCAAGAGTT AGCTTTGATC
    ATCCACCCTA AGGCTGGTGT ACAAGAACAA CCTATCGAAG CACGACCTTT ACGCTCTGTC
    TCTTCGAAGA AACCATCTTT TCAACCTGAA AAATACGGAC ACAAAAGTTA CCTGGAGAAG
    AATGGACCTG CGTCTAATGA TCCCGCACAA AGTGCTACAA AAAGGAAAAG ACGATTTTGG
    ACGCTGGCAG AAGTAGAGAT GCTTAGGGTT GGTGTGCAGA AATTCCCTGG CGAGAGGAAT
    ATTCCATGGC GCAAAATCTT GCAATTTGGT CGGGATGTGT TTCATGATGA ACGGGCTCCA
    AGCGACCTCA AGGACAAGTG GAAGACGTTA AACAAAATTC CTTCTGACAC GGGGAAATGG
    GTAAGCCTTT CAACTGAAAG ACAACCGAAT TACTATGTGT CTGAAGTTAG TTCTGAATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OAb39188
    Clone ID Related Accession (Same CDS sequence) NM_001340797.1
    Accession Version NM_001340797.1 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1830bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-13
    Organism Arabidopsis thaliana(thale cress)
    Product Homeodomain-like superfamily protein
    Comment Comment: REVIEWED REFSEQ: This record has been curated by TAIR and Araport. This record is derived from an annotated genomic sequence (NC_003075).

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    ATGAGTTCTC GAATTTTATC CTCCGATTCG GACGACGTTG ATGAAGAAAA CCCGAAAACT 
    CACGAGAATG GTCCAATTGG AGGAAAGACT CAAAATTTAG GGCAAAGCAA GGGAGGTGAT
    AGTGATAATG TTGTAAAGAC TAATACTTGT TTCGTGTGTG ATGGGAAAGA CAATTGGGTT
    TTGGTATGTT ACGGAGAGGA ATGTACTATA GCTATTCATC AGAGTTGTGC ATCTGATGAA
    CCTGATTTCG ATGAATTTGG AAATTTCTAT TGTCCTTATT GTTGGTATAA GCGTGTAGTT
    GTCAAGTGTT TGGAGTTAGG GAAGAAGCTT ATGCTGACTG ACAAGTCTAG GAAGGGATGT
    AGAGAGAGTT TAGGAGGAGT AGATGTGGGT TTAATGATGG AGAAAGAAGC TGGAGGTGTT
    GAGAATGTAG TGGAGGTTAA TGTTTCTGGA GCAAGTGGTA TGGTTAGTGG GAAGAGAAGG
    GAAGGTGATG GATTAAACAA TAAATGGATA GTGATCGAGA AGAGTCAGAA AATGCAAAAA
    GTTGCTGCTG AAACTCATTC TCGGGAAAAT TCTAAGGCTG ATGATATTGA TTCGGATAAG
    GGAAGAAAGC AGCGAGGAAG ATTTAATGAG AAGAATTATG AAATTTCATA TGCGTGCATT
    TCTAATGCAG GTGAGGGAAG AAAGGGAAGG GTAAGAAGAG GTAATGAGAA AAATCATCAA
    GCACCAGAAG CGCACAGTAT TGATGTTGGT GGGGAAAGAA AGCGACAGAG AAGATGCGAT
    GATATAAACC ATGAAAAAGC ACAACCGCAC AGTTTTGCTG TTGGTATCAA AACAAAAGAG
    AAGAGGAGAT ACAGTGAGAA GAACCAGCAA AACAAAACAG TTGCAACTAC TCATGAACAC
    GACGTCTTAA CTAATGATGG AAGAACAGAA GCCCGCGATT CTGATTTCGG TGAGGGAAGA
    AGTGGGCAAG GATGTTTCCA TGAGAATAAC CAGCAAACGA AAGTGTCGTC TACTGAAAGA
    TGCGAGCAGG AAATCCCTAG GACCAATAAA AGAGTGTCAC TCGGTTCTGG ATTAGGGGAG
    GGGCGATATC GGGAGGGAAG ACATATTGAA AAGAATCAGC ATACCGAAAC TGTTAAAACT
    GAAACTCATG GGAAGGAAGT TTCTAAGGAT AGGAAGAGAA AGCGGGAAAG AGGAGTGGAA
    AGAGATGGGG ATGAGTTCTA TTTGGCGGAG AATCAAGACA GACAATGCCA AGCTGATATG
    AGAAATGATG ATGTGGCCTT CAATAAGCAA GCGACTGGTT TCAGCACAGT TGAACAAGTA
    GAGCGAAAGT CTGTATCATC TATTTCATCT CCGGAGTCTA CAAACAATGT TAACGACCCT
    AATGTTGCTT TTCAAGAGTT AGCTTTGATC ATCCACCCTA AGGCTGGTGT ACAAGAACAA
    CCTATCGAAG CACGACCTTT ACGCTCTGTC TCTTCGAAGA AACCATCTTT TCAACCTGAA
    AAATACGGAC ACAAAAGTTA CCTGGAGAAG AATGGACCTG CGTCTAATGA TCCCGCACAA
    AGTGCTACAA AAAGGAAAAG ACGATTTTGG ACGCTGGCAG AAGTAGAGAT GCTTAGGGTT
    GGTGTGCAGA AATTCCCTGG CGAGAGGAAT ATTCCATGGC GCAAAATCTT GCAATTTGGT
    CGGGATGTGT TTCATGATGA ACGGGCTCCA AGCGACCTCA AGGACAAGTG GAAGACGTTA
    AACAAAATTC CTTCTGACAC GGGGAAATGG GTAAGCCTTT CAACTGAAAG ACAACCGAAT
    TACTATGTGT CTGAAGTTAG TTCTGAATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_001328952.1
    CDS73..1902
    Translation

    Target ORF information:

    RefSeq Version NM_001340797.1
    Organism Arabidopsis thaliana(thale cress)
    Definition Arabidopsis thaliana Homeodomain-like superfamily protein (AT4G12670), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_001340797.1

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    ATGAGTTCTC GAATTTTATC CTCCGATTCG GACGACGTTG ATGAAGAAAA CCCGAAAACT 
    CACGAGAATG GTCCAATTGG AGGAAAGACT CAAAATTTAG GGCAAAGCAA GGGAGGTGAT
    AGTGATAATG TTGTAAAGAC TAATACTTGT TTCGTGTGTG ATGGGAAAGA CAATTGGGTT
    TTGGTATGTT ACGGAGAGGA ATGTACTATA GCTATTCATC AGAGTTGTGC ATCTGATGAA
    CCTGATTTCG ATGAATTTGG AAATTTCTAT TGTCCTTATT GTTGGTATAA GCGTGTAGTT
    GTCAAGTGTT TGGAGTTAGG GAAGAAGCTT ATGCTGACTG ACAAGTCTAG GAAGGGATGT
    AGAGAGAGTT TAGGAGGAGT AGATGTGGGT TTAATGATGG AGAAAGAAGC TGGAGGTGTT
    GAGAATGTAG TGGAGGTTAA TGTTTCTGGA GCAAGTGGTA TGGTTAGTGG GAAGAGAAGG
    GAAGGTGATG GATTAAACAA TAAATGGATA GTGATCGAGA AGAGTCAGAA AATGCAAAAA
    GTTGCTGCTG AAACTCATTC TCGGGAAAAT TCTAAGGCTG ATGATATTGA TTCGGATAAG
    GGAAGAAAGC AGCGAGGAAG ATTTAATGAG AAGAATTATG AAATTTCATA TGCGTGCATT
    TCTAATGCAG GTGAGGGAAG AAAGGGAAGG GTAAGAAGAG GTAATGAGAA AAATCATCAA
    GCACCAGAAG CGCACAGTAT TGATGTTGGT GGGGAAAGAA AGCGACAGAG AAGATGCGAT
    GATATAAACC ATGAAAAAGC ACAACCGCAC AGTTTTGCTG TTGGTATCAA AACAAAAGAG
    AAGAGGAGAT ACAGTGAGAA GAACCAGCAA AACAAAACAG TTGCAACTAC TCATGAACAC
    GACGTCTTAA CTAATGATGG AAGAACAGAA GCCCGCGATT CTGATTTCGG TGAGGGAAGA
    AGTGGGCAAG GATGTTTCCA TGAGAATAAC CAGCAAACGA AAGTGTCGTC TACTGAAAGA
    TGCGAGCAGG AAATCCCTAG GACCAATAAA AGAGTGTCAC TCGGTTCTGG ATTAGGGGAG
    GGGCGATATC GGGAGGGAAG ACATATTGAA AAGAATCAGC ATACCGAAAC TGTTAAAACT
    GAAACTCATG GGAAGGAAGT TTCTAAGGAT AGGAAGAGAA AGCGGGAAAG AGGAGTGGAA
    AGAGATGGGG ATGAGTTCTA TTTGGCGGAG AATCAAGACA GACAATGCCA AGCTGATATG
    AGAAATGATG ATGTGGCCTT CAATAAGCAA GCGACTGGTT TCAGCACAGT TGAACAAGTA
    GAGCGAAAGT CTGTATCATC TATTTCATCT CCGGAGTCTA CAAACAATGT TAACGACCCT
    AATGTTGCTT TTCAAGAGTT AGCTTTGATC ATCCACCCTA AGGCTGGTGT ACAAGAACAA
    CCTATCGAAG CACGACCTTT ACGCTCTGTC TCTTCGAAGA AACCATCTTT TCAACCTGAA
    AAATACGGAC ACAAAAGTTA CCTGGAGAAG AATGGACCTG CGTCTAATGA TCCCGCACAA
    AGTGCTACAA AAAGGAAAAG ACGATTTTGG ACGCTGGCAG AAGTAGAGAT GCTTAGGGTT
    GGTGTGCAGA AATTCCCTGG CGAGAGGAAT ATTCCATGGC GCAAAATCTT GCAATTTGGT
    CGGGATGTGT TTCATGATGA ACGGGCTCCA AGCGACCTCA AGGACAAGTG GAAGACGTTA
    AACAAAATTC CTTCTGACAC GGGGAAATGG GTAAGCCTTT CAACTGAAAG ACAACCGAAT
    TACTATGTGT CTGAAGTTAG TTCTGAATGA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

  • PubMed

    Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.
    Nature402(6763)769-77(1999 Dec)
    Mayer K,Sch?ller C,Wambutt R,Murphy G,Volckaert G,Pohl T,D?sterh?ft A,Stiekema W,Entian KD,Terryn N,Harris B,Ansorge W,Brandt P,Grivell L,Rieger M,Weichselgartner M,de Simone V,Obermaier B,Mache R,M?ller M,Kreis M,Delseny M,Puigdomenech P,Watson M,Schmidtheini T,Reichert B,Portatelle D,Perez-Alonso M,Boutry M,Bancroft I,Vos P,Hoheisel J,Zimmermann W,Wedler H,Ridley P,Langham SA,McCullagh B,Bilham L,Robben J,Van der Schueren J,Grymonprez B,Chuang YJ,Vandenbussche F,Braeken M,Weltjens I,Voet M,Bastiaens I,Aert R,Defoor E,Weitzenegger T,Bothe G,Ramsperger U,Hilbert H,Braun M,Holzer E,Brandt A,Peters S,van Staveren M,Dirske W,Mooijman P,Klein Lankhorst R,Rose M,Hauf J,K?tter P,Berneiser S,Hempel S,Feldpausch M,Lamberth S,Van den Daele H,De Keyser A,Buysshaert C,Gielen J,Villarroel R,De Clercq R,Van Montagu M,Rogers J,Cronin A,Quail M,Bray-Allen S,Clark L,Doggett J,Hall S,Kay M,Lennard N,McLay K,Mayes R,Pettett A,Rajandream MA,Lyne M,Benes V,Rechmann S,Borkova D,Bl?cker H,Scharfe M,Grimm M,L?hnert TH,Dose S,de Haan M,Maarse A,Sch?fer M,M?ller-Auer S,Gabel C,Fuchs M,Fartmann B,Granderath K,Dauner D,Herzl A,Neumann S,Argiriou A,Vitale D,Liguori R,Piravandi E,Massenet O,Quigley F,Clabauld G,M?ndlein A,Felber R,Schnabl S,Hiller R,Schmidt W,Lecharny A,Aubourg S,Chefdor F,Cooke R,Berger C,Montfort A,Casacuberta E,Gibbons T,Weber N,Vandenbol M,Bargues M,Terol J,Torres A,Perez-Perez A,Purnelle B,Bent E,Johnson S,Tacon D,Jesse T,Heijnen L,Schwarz S,Scholler P,Heber S,Francs P,Bielke C,Frishman D,Haase D,Lemcke K,Mewes HW,Stocker S,Zaccaria P,Bevan M,Wilson RK,de la Bastide M,Habermann K,Parnell L,Dedhia N,Gnoj L,Schutz K,Huang E,Spiegel L,Sehkon M,Murray J,Sheet P,Cordes M,Abu-Threideh J,Stoneking T,Kalicki J,Graves T,Harmon G,Edwards J,Latreille P,Courtney L,Cloud J,Abbott A,Scott K,Johnson D,Minx P,Bentley D,Fulton B,Miller N,Greco T,Kemp K,Kramer J,Fulton L,Mardis E,Dante M,Pepin K,Hillier L,Nelson J,Spieth J,Ryan E,Andrews S,Geisel C,Layman D,Du H,Ali J,Berghoff A,Jones K,Drone K,Cotton M,Joshu C,Antonoiu B,Zidanic M,Strong C,Sun H,Lamar B,Yordan C,Ma P,Zhong J,Preston R,Vil D,Shekher M,Matero A,Shah R,Swaby IK,O'Shaughnessy A,Rodriguez M,Hoffmann J,Till S,Granat S,Shohdy N,Hasegawa A,Hameed A,Lodhi M,Johnson A,Chen E,Marra M,Martienssen R,McCombie WR