CSK cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSK
Entrez Gene ID	509246
Full Name	C-terminal Src kinase
General protein information	Preferred Names C-terminal Src kinase Names tyrosine-protein kinase CSK C-SRC kinase CSK, non-receptor tyrosine kinase c-src tyrosine kinase
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024981704.1	XP_024837472.1	tyrosine-protein kinase CSK isoform X1
NM_001075397.1	NP_001068865.1	tyrosine-protein kinase CSK

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Csk	NP_001025210.1
Drosophila melanogaster (fruit fly)	Csk	NP_788638.1
Homo sapiens (human)	CSK	NP_004374.1
Bos taurus (cattle)	CSK	NP_001068865.1
Danio rerio (zebrafish)	csk	NP_001071067.1
Xenopus tropicalis (tropical clawed frog)	csk	NP_001135615.1
Mus musculus (house mouse)	Csk	NP_031809.2
Gallus gallus (chicken)	CSK	NP_990756.1
Caenorhabditis elegans (roundworm)	csk-1	NP_001021778.1
Pan troglodytes (chimpanzee)	CSK	XP_001138334.3
	CSK	XP_001101521.1
Canis lupus familiaris (dog)	CSK	XP_005638681.1

Gene Ontology
Bibliography

Related articles in PubMed

Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Pan S, World CJ, Kovacs CJ, Berk BC
Arteriosclerosis, thrombosis, and vascular biology29(6)895-901(2009 Jun)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.
Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD
American journal of physiology. Lung cellular and molecular physiology295(4)L688-97(2008 Oct)

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.
Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, Brookes PS, Sheu SS, Abe J
The Journal of biological chemistry280(28)26383-96(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Title: Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.

Src family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase in pulmonary artery endothelium.
Title: Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.

Dok-4 has a role as an anchoring molecule for the tyrosine kinase c-Src, and in turn as a regulator of TNF-alpha-mediated ROS production and NF-kappaB activation
Title: Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.

The following CSK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42433	NM_001075397.1 Latest version!	Bos taurus C-terminal Src kinase (CSK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa228274	XM_024981704.1 Latest version!	Bos taurus C-terminal Src kinase (CSK), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSK ( NM_001075397.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001068865.1 Bos taurus C-terminal Src kinase (CSK), mRNA.

Price & Availability↑

CloneID	OBa42433
Clone ID Related Accession (Same CDS sequence)	NM_001075397.1
Accession Version	NM_001075397.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Bos taurus(cattle)
Product	tyrosine-protein kinase CSK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC120437.1. On or before Oct 4, 2006 this sequence version replaced XM_879052.1, XM_866784.1, XM_879111.1, XM_879139.1, XM_586170.2. ##Evidence-Data-START## Transcript exon combination :: BC120437.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGTCAGCAA TTCAGGCTGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTT 
CACGGCACTG CTGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAATTG GTACAAAGCC AAGAACAAGG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGGGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTCATG 
CCCTGGTTCC ATGGCAAGAT CACGCGGGAA CAGGCAGAGC GGCTCCTGTG CCCACCGGAG 
ACAGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GGGACTACAC GCTGTGCGTG 
AGCTGTGATG GCAAGGTGGA GCATTACCGC ATCATGTACC ACGCCAGCAA GCTCAGCATC 
GATGAAGAGG TGTACTTTGA GAACCTCATG CAGCTGGTGG AGCACTACAC CTCAGATGCA 
GATGGCCTCT GTACTCGCCT CATCAAGCCA AAGGTCATGG AGGGCACCGT GGCCGCCCAG 
GATGAGTTCT TCCGCAGTGG CTGGGCGCTG AACATGAAGG ACCTGAAGCT GCTGCAGACC 
ATAGGGAAGG GGGAGTTTGG AGACGTGATG CTGGGTGACT ACCGAGGGAA CAAAGTCGCT 
GTCAAGTGCA TTAAGAACGA TGCCACTGCA CAGGCCTTCC TGGCTGAAGC CTCCGTCATG 
ACGCAACTCC GGCATAGCAA CCTGGTACAG CTTCTGGGCG TGATCGTAGA GGAGAAGAGC 
GGGCTGTACA TCGTTACCGA GTACATGGCC AAGGGGAGTC TAGTGGACTA CCTGCGGTCT 
CGGGGTCGGT CGGTGCTTGG CGGAGACTGT CTCCTCAAGT TCTCACTAGA CGTCTGTGAG 
GCCATGGAAT ACCTGGAGGG CAACAACTTC GTGCATCGGG ATCTGGCTGC CCGCAACGTG 
CTGGTGTCTG AGGACAATGT GGCCAAGGTC AGCGACTTCG GCCTCACCAA GGAGGCCTCC 
AGCACCCAGG ACACGGGCAA GCTGCCGGTC AAGTGGACAG CCCCCGAGGC CCTAAGAGAG 
AAGAAATTCT CCACCAAGTC TGATGTGTGG AGTTTCGGGA TCCTTCTCTG GGAAATCTAC 
TCTTTCGGGC GAGTGCCTTA TCCAAGAATT CCCCTGAAGG ACGTCGTCCC GCGGGTGGAG 
AAGGGCTACA AGATGGATGC CCCTGACGGC TGCCCACCTG CAGTCTACGA GGTCATGAAG 
AACTGCTGGC ACCTGGATGC CGCCACGCGG CCCTCCTTCC TGCAGCTCCG CGAGCAGCTC 
GAGCGCATCA AGACCCACGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001068865.1
CDS	291..1643
Translation	MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLCPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFFRSGWALNMKDLKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPSFLQLREQLERIKTHELHL

Target ORF information:

RefSeq Version	NM_001075397.1
Organism	Bos taurus(cattle)
Definition	Bos taurus C-terminal Src kinase (CSK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001075397.1

ORF Insert Sequence:

ATGTCAGCAA TTCAGGCTGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTT 
CACGGCACTG CTGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 
GTCACCAAGG ACCCCAATTG GTACAAAGCC AAGAACAAGG TGGGCCGTGA GGGCATCATC 
CCAGCCAACT ATGTCCAGAA GCGGGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTCATG 
CCCTGGTTCC ATGGCAAGAT CACGCGGGAA CAGGCAGAGC GGCTCCTGTG CCCACCGGAG 
ACAGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GGGACTACAC GCTGTGCGTG 
AGCTGTGATG GCAAGGTGGA GCATTACCGC ATCATGTACC ACGCCAGCAA GCTCAGCATC 
GATGAAGAGG TGTACTTTGA GAACCTCATG CAGCTGGTGG AGCACTACAC CTCAGATGCA 
GATGGCCTCT GTACTCGCCT CATCAAGCCA AAGGTCATGG AGGGCACCGT GGCCGCCCAG 
GATGAGTTCT TCCGCAGTGG CTGGGCGCTG AACATGAAGG ACCTGAAGCT GCTGCAGACC 
ATAGGGAAGG GGGAGTTTGG AGACGTGATG CTGGGTGACT ACCGAGGGAA CAAAGTCGCT 
GTCAAGTGCA TTAAGAACGA TGCCACTGCA CAGGCCTTCC TGGCTGAAGC CTCCGTCATG 
ACGCAACTCC GGCATAGCAA CCTGGTACAG CTTCTGGGCG TGATCGTAGA GGAGAAGAGC 
GGGCTGTACA TCGTTACCGA GTACATGGCC AAGGGGAGTC TAGTGGACTA CCTGCGGTCT 
CGGGGTCGGT CGGTGCTTGG CGGAGACTGT CTCCTCAAGT TCTCACTAGA CGTCTGTGAG 
GCCATGGAAT ACCTGGAGGG CAACAACTTC GTGCATCGGG ATCTGGCTGC CCGCAACGTG 
CTGGTGTCTG AGGACAATGT GGCCAAGGTC AGCGACTTCG GCCTCACCAA GGAGGCCTCC 
AGCACCCAGG ACACGGGCAA GCTGCCGGTC AAGTGGACAG CCCCCGAGGC CCTAAGAGAG 
AAGAAATTCT CCACCAAGTC TGATGTGTGG AGTTTCGGGA TCCTTCTCTG GGAAATCTAC 
TCTTTCGGGC GAGTGCCTTA TCCAAGAATT CCCCTGAAGG ACGTCGTCCC GCGGGTGGAG 
AAGGGCTACA AGATGGATGC CCCTGACGGC TGCCCACCTG CAGTCTACGA GGTCATGAAG 
AACTGCTGGC ACCTGGATGC CGCCACGCGG CCCTCCTTCC TGCAGCTCCG CGAGCAGCTC 
GAGCGCATCA AGACCCACGA GCTGCACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSK ( XM_024981704.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024837472.1 Bos taurus C-terminal Src kinase (CSK), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa228274
Clone ID Related Accession (Same CDS sequence)	XM_024981704.1
Accession Version	XM_024981704.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	tyrosine-protein kinase CSK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037348.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCTCAC CATTGTGGCT GTCACCAAGC TGGTTCCATG GCAAGATCAC GCGGGAACAG 
GCAGAGCGGC TCCTGTGCCC ACCGGAGACA GGCCTGTTCC TGGTGCGGGA GAGCACCAAC 
TACCCCGGGG ACTACACGCT GTGCGTGAGC TGTGATGGCA AGGTGGAGCA TTACCGCATC 
ATGTACCACG CCAGCAAGCT CAGCATCGAT GAAGAGGTGT ACTTTGAGAA CCTCATGCAG 
CTGGTGGAGC ACTACACCTC AGATGCAGAT GGCCTCTGTA CTCGCCTCAT CAAGCCAAAG 
GTCATGGAGG GCACCGTGGC CGCCCAGGAT GAGTTCTTCC GCAGTGGCTG GGCGCTGAAC 
ATGAAGGACC TGAAGCTGCT GCAGACCATA GGGAAGGGGG AGTTTGGAGA CGTGATGCTG 
GGTGACTACC GAGGGAACAA AGTCGCTGTC AAGTGCATTA AGAACGATGC CACTGCACAG 
GCCTTCCTGG CTGAAGCCTC CGTCATGACG CAACTCCGGC ATAGCAACCT GGTACAGCTT 
CTGGGCGTGA TCGTAGAGGA GAAGAGCGGG CTGTACATCG TTACCGAGTA CATGGCCAAG 
GGGAGTCTAG TGGACTACCT GCGGTCTCGG GGTCGGTCGG TGCTTGGCGG AGACTGTCTC 
CTCAAGTTCT CACTAGACGT CTGTGAGGCC ATGGAATACC TGGAGGGCAA CAACTTCGTG 
CATCGGGATC TGGCTGCCCG CAACGTGCTG GTGTCTGAGG ACAATGTGGC CAAGGTCAGC 
GACTTCGGCC TCACCAAGGA GGCCTCCAGC ACCCAGGACA CGGGCAAGCT GCCGGTCAAG 
TGGACAGCCC CCGAGGCCCT AAGAGAGAAG AAATTCTCCA CCAAGTCTGA TGTGTGGAGT 
TTCGGGATCC TTCTCTGGGA AATCTACTCT TTCGGGCGAG TGCCTTATCC AAGAATTCCC 
CTGAAGGACG TCGTCCCGCG GGTGGAGAAG GGCTACAAGA TGGATGCCCC TGACGGCTGC 
CCACCTGCAG TCTACGAGGT CATGAAGAAC TGCTGGCACC TGGATGCCGC CACGCGGCCC 
TCCTTCCTGC AGCTCCGCGA GCAGCTCGAG CGCATCAAGA CCCACGAGCT GCACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024837472.1
CDS	805..1944
Translation	MCSPLWLSPSWFHGKITREQAERLLCPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFFRSGWALNMKDLKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPSFLQLREQLERIKTHELHL

Target ORF information:

RefSeq Version	XM_024981704.1
Organism	Bos taurus(cattle)
Definition	Bos taurus C-terminal Src kinase (CSK), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024981704.1

ORF Insert Sequence:

ATGTGCTCAC CATTGTGGCT GTCACCAAGC TGGTTCCATG GCAAGATCAC GCGGGAACAG 
GCAGAGCGGC TCCTGTGCCC ACCGGAGACA GGCCTGTTCC TGGTGCGGGA GAGCACCAAC 
TACCCCGGGG ACTACACGCT GTGCGTGAGC TGTGATGGCA AGGTGGAGCA TTACCGCATC 
ATGTACCACG CCAGCAAGCT CAGCATCGAT GAAGAGGTGT ACTTTGAGAA CCTCATGCAG 
CTGGTGGAGC ACTACACCTC AGATGCAGAT GGCCTCTGTA CTCGCCTCAT CAAGCCAAAG 
GTCATGGAGG GCACCGTGGC CGCCCAGGAT GAGTTCTTCC GCAGTGGCTG GGCGCTGAAC 
ATGAAGGACC TGAAGCTGCT GCAGACCATA GGGAAGGGGG AGTTTGGAGA CGTGATGCTG 
GGTGACTACC GAGGGAACAA AGTCGCTGTC AAGTGCATTA AGAACGATGC CACTGCACAG 
GCCTTCCTGG CTGAAGCCTC CGTCATGACG CAACTCCGGC ATAGCAACCT GGTACAGCTT 
CTGGGCGTGA TCGTAGAGGA GAAGAGCGGG CTGTACATCG TTACCGAGTA CATGGCCAAG 
GGGAGTCTAG TGGACTACCT GCGGTCTCGG GGTCGGTCGG TGCTTGGCGG AGACTGTCTC 
CTCAAGTTCT CACTAGACGT CTGTGAGGCC ATGGAATACC TGGAGGGCAA CAACTTCGTG 
CATCGGGATC TGGCTGCCCG CAACGTGCTG GTGTCTGAGG ACAATGTGGC CAAGGTCAGC 
GACTTCGGCC TCACCAAGGA GGCCTCCAGC ACCCAGGACA CGGGCAAGCT GCCGGTCAAG 
TGGACAGCCC CCGAGGCCCT AAGAGAGAAG AAATTCTCCA CCAAGTCTGA TGTGTGGAGT 
TTCGGGATCC TTCTCTGGGA AATCTACTCT TTCGGGCGAG TGCCTTATCC AAGAATTCCC 
CTGAAGGACG TCGTCCCGCG GGTGGAGAAG GGCTACAAGA TGGATGCCCC TGACGGCTGC 
CCACCTGCAG TCTACGAGGT CATGAAGAAC TGCTGGCACC TGGATGCCGC CACGCGGCCC 
TCCTTCCTGC AGCTCCGCGA GCAGCTCGAG CGCATCAAGA CCCACGAGCT GCACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology29(6)895-901(2009 Jun)
Pan S,World CJ,Kovacs CJ,Berk BC

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.
American journal of physiology. Lung cellular and molecular physiology295(4)L688-97(2008 Oct)
Chang R,Chicoine LG,Cui H,Kanagy NL,Walker BR,Liu Y,English BK,Nelin LD

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.
The Journal of biological chemistry280(28)26383-96(2005 Jul)
Itoh S,Lemay S,Osawa M,Che W,Duan Y,Tompkins A,Brookes PS,Sheu SS,Abe J

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CSK cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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