OAZ2 cDNA ORF clone, Equus caballus(horse)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ2
Entrez Gene ID	100066770
Full Name	ornithine decarboxylase antizyme 2
Gene Type	protein-coding
Organism	Equus caballus(horse)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001130486.2	NP_001123958.1	ornithine decarboxylase antizyme 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Annotation of the Protein Coding Regions of the Equine Genome.
Hestand MS, Kalbfleisch TS, Coleman SJ, Zeng Z, Liu J, Orlando L, MacLeod JN
PloS one10(6)e0124375(2015)

Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse.
Tryon RC, White SD, Bannasch DL
Genomics90(1)93-102(2007 Jul)

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHb39681	NM_001130486.2 Latest version!	Equus caballus ornithine decarboxylase antizyme 2 (OAZ2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ2 ( NM_001130486.2 ) cDNA ORF clone, Equus caballus(horse) -> NP_001123958.1 Equus caballus ornithine decarboxylase antizyme 2 (OAZ2), mRNA.

Price & Availability↑

CloneID	OHb39681
Clone ID Related Accession (Same CDS sequence)	NM_001130486.2
Accession Version	NM_001130486.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-01-28
Organism	Equus caballus(horse)
Product	ornithine decarboxylase antizyme 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD466015.1, EF397508.1 and DN507624.1. On Jun 23, 2011 this sequence version replaced NM_001130486.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2452530, SAMEA2452531 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END##

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAACGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTA TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGGCGGG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GCCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTCAT GGTTTACTCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001123958.1
CDS	join(171..266,268..741)
Translation	MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFIEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYSLDQNLSDED

Target ORF information:

RefSeq Version	NM_001130486.2
Organism	Equus caballus(horse)
Definition	Equus caballus ornithine decarboxylase antizyme 2 (OAZ2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130486.2

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TAGTATTTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCAGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTCTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAACGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTA TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGGCGGG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GCCATCCCTG TGTCCCCTCT CGGCCAGATG TGATGTTCAT GGTTTACTCC 
CTGGACCAGA ACTTGTCCGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Annotation of the Protein Coding Regions of the Equine Genome.
PloS one10(6)e0124375(2015)
Hestand MS,Kalbfleisch TS,Coleman SJ,Zeng Z,Liu J,Orlando L,MacLeod JN

Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse.
Genomics90(1)93-102(2007 Jul)
Tryon RC,White SD,Bannasch DL

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

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OAZ2 cDNA ORF clone, Equus caballus(horse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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