PRNP cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRNP
Entrez Gene ID	485783
Full Name	prion protein
Synonyms	PrP
General protein information	Preferred Names prion protein Names major prion protein prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013423.1	NP_001013441.1	major prion protein precursor
XM_005634692.2	XP_005634749.1	major prion protein isoform X1
XM_005634691.3	XP_005634748.1	major prion protein isoform X1
XM_005634691.2	XP_005634748.1	major prion protein isoform X1
XM_005634692.3	XP_005634749.1	major prion protein isoform X1
XM_022408814.1	XP_022264522.1	major prion protein isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genetic predictions of prion disease susceptibility in carnivore species based on variability of the prion gene coding region.
Stewart P, Campbell L, Skogtvedt S, Griffin KA, Arnemo JM, Tryland M, Girling S, Miller MW, Tranulis MA, Goldmann W
PloS one7(12)e50623(2012)

Molecular dynamics studies on the structural stability of wild-type dog prion protein.
Zhang J, Liu DD
Journal of biomolecular structure & dynamics28(6)861-9(2011 Jun)

Polymorphisms of the prion protein gene (PRNP) in the Tibetan Mastiff.
Zhang JE, Sun B, Pang WY, Qiao JW, Kouadir M, Yang LF, Zhao DM
Animal genetics40(6)1001-2(2009 Dec)

Amino acid sequence of the Pekingese dog prion protein gene.
Wu C, Pang W, Yang J, Zhou X, Zhao D
Xenotransplantation13(5)471-4(2006 Sep)

Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein.
Wopfner F, Weidenh?fer G, Schneider R, von Brunn A, Gilch S, Schwarz TF, Werner T, Sch?tzl HM
Journal of molecular biology289(5)1163-78(1999 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

paper studies the molecular structural dynamics of wild-type dog prion protein; comparison analyses with rabbit prion protein show that the dog prion protein has stable molecular structures whether under neutral or low pH environments
Title: Molecular dynamics studies on the structural stability of wild-type dog prion protein.

The observed codon 101 polymorphism is unlikely to affect the function of PrP in Tibetan Mastiff.
Title: Polymorphisms of the prion protein gene (PRNP) in the Tibetan Mastiff.

open reading frame of the prion protein (Prnp) gene from 16 Pekingese dogs was cloned and screened for polymorphisms; one nucleotide polymorphism (G489C) was found
Title: Amino acid sequence of the Pekingese dog prion protein gene.

The following PRNP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRNP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe00566	NM_001013423.1 Latest version!	Canis lupus familiaris prion protein (PRNP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00
OCe24436	XM_005634692.3 Latest version!	Canis lupus familiaris prion protein (PRNP), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00
OCe24436	XM_022408814.1 Latest version!	Canis lupus familiaris prion protein (PRNP), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00
OCe24436	XM_005634691.3 Latest version!	Canis lupus familiaris prion protein (PRNP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00
View Old Accession Versions >>
OCe24436	XM_005634691.2	Canis lupus familiaris prion protein (PRNP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00
OCe24436	XM_005634692.2	Canis lupus familiaris prion protein (PRNP), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRNP ( NM_001013423.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001013441.1 Canis lupus familiaris prion protein (PRNP), mRNA.

Price & Availability↑

CloneID	OCe00566
Clone ID Related Accession (Same CDS sequence)	NM_001013423.1
Accession Version	NM_001013423.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Canis lupus familiaris(dog)
Product	major prion protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF042843.1. On Jan 21, 2008 this sequence version replaced XM_542906.2. ##Evidence-Data-START## Transcript is intronless :: FJ870766.1, FJ870767.1 [ECO:0000345] ##Evidence-Data-END##

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGAGC AGGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCCG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013441.1
CDS	1..774
Translation	MVKSHIGGWILLLFVATWSDVGLCKKRPKPGGWNTGGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHSQWGKPNKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPEQVYYRPVDQYSNQNNFVRDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILFSPPPVILLISLLILLIVG

Target ORF information:

RefSeq Version	NM_001013423.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris prion protein (PRNP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013423.1

ORF Insert Sequence:

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGAGC AGGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCCG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRNP ( XM_005634692.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005634749.1 Canis lupus familiaris prion protein (PRNP), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe24436
Clone ID Related Accession (Same CDS sequence)	XM_005634692.2 , XM_005634691.3 , XM_005634691.2 , XM_005634692.3 , XM_022408814.1
Accession Version	XM_005634692.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	major prion protein isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726101.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005634692.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005634749.1
CDS	207..980
Translation	MVKSHIGGWILLLFVATWSDVGLCKKRPKPGGWNTGGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHSQWGKPNKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPDQVYYRPVDQYSNQNNFVRDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILFSPPPVILLISLLILLIVG

Target ORF information:

RefSeq Version	XM_005634692.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris prion protein (PRNP), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005634692.2

ORF Insert Sequence:

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRNP ( XM_005634691.3 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005634748.1 Canis lupus familiaris prion protein (PRNP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe24436
Clone ID Related Accession (Same CDS sequence)	XM_005634692.2 , XM_005634691.3 , XM_005634691.2 , XM_005634692.3 , XM_022408814.1
Accession Version	XM_005634691.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	major prion protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006606.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005634691.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005634748.1
CDS	266..1039
Translation	MVKSHIGGWILLLFVATWSDVGLCKKRPKPGGWNTGGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHSQWGKPNKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPDQVYYRPVDQYSNQNNFVRDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILFSPPPVILLISLLILLIVG

Target ORF information:

RefSeq Version	XM_005634691.3
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris prion protein (PRNP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005634691.3

ORF Insert Sequence:

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRNP ( XM_005634691.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005634748.1 Canis lupus familiaris prion protein (PRNP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe24436
Clone ID Related Accession (Same CDS sequence)	XM_005634692.2 , XM_005634691.3 , XM_005634691.2 , XM_005634692.3 , XM_022408814.1
Accession Version	XM_005634691.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	major prion protein isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726101.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005634691.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005634748.1
CDS	301..1074
Translation	MVKSHIGGWILLLFVATWSDVGLCKKRPKPGGWNTGGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHSQWGKPNKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPDQVYYRPVDQYSNQNNFVRDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILFSPPPVILLISLLILLIVG

Target ORF information:

RefSeq Version	XM_005634691.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris prion protein (PRNP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005634691.2

ORF Insert Sequence:

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRNP ( XM_005634692.3 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005634749.1 Canis lupus familiaris prion protein (PRNP), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe24436
Clone ID Related Accession (Same CDS sequence)	XM_005634692.2 , XM_005634691.3 , XM_005634691.2 , XM_005634692.3 , XM_022408814.1
Accession Version	XM_005634692.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	major prion protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006606.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005634692.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005634749.1
CDS	120..893
Translation	MVKSHIGGWILLLFVATWSDVGLCKKRPKPGGWNTGGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHSQWGKPNKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPDQVYYRPVDQYSNQNNFVRDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILFSPPPVILLISLLILLIVG

Target ORF information:

RefSeq Version	XM_005634692.3
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris prion protein (PRNP), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005634692.3

ORF Insert Sequence:

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRNP ( XM_022408814.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_022264522.1 Canis lupus familiaris prion protein (PRNP), transcript variant X3, mRNA.

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CloneID	OCe24436
Clone ID Related Accession (Same CDS sequence)	XM_005634692.2 , XM_005634691.3 , XM_005634691.2 , XM_005634692.3 , XM_022408814.1
Accession Version	XM_022408814.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	major prion protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006606.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_022264522.1
CDS	159..932
Translation	MVKSHIGGWILLLFVATWSDVGLCKKRPKPGGWNTGGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHSQWGKPNKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPDQVYYRPVDQYSNQNNFVRDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQKESEAYYQRGASAILFSPPPVILLISLLILLIVG

Target ORF information:

RefSeq Version	XM_022408814.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris prion protein (PRNP), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_022408814.1

ORF Insert Sequence:

ATGGTGAAAA GCCACATAGG CGGCTGGATC CTGCTTCTCT TTGTGGCCAC ATGGAGTGAC 
GTGGGCCTCT GCAAGAAGCG GCCGAAGCCT GGAGGATGGA ACACAGGGGG TGGGAGCCGA 
TACCCAGGCC AGGGTAGCCC TGGAGGCAAC CGCTACCCAC CCCAGGGCGG TGGTGGCTGG 
GGTCAGCCCC ATGGTGGTGG CTGGGGTCAG CCTCATGGTG GCGGCTGGGG TCAGCCCCAC 
GGTGGTGGCT GGGGACAGCC ACATGGTGGT GGTGGTTGGG GTCAAGGTGG TGGCAGCCAC 
AGTCAGTGGG GCAAGCCCAA TAAGCCCAAA ACCAACATGA AGCACGTGGC AGGAGCCGCA 
GCAGCCGGGG CGGTAGTAGG GGGCCTTGGT GGCTACATGC TGGGGAGTGC CATGAGCAGG 
CCACTCATTC ATTTTGGCAA TGACTATGAG GACCGTTACT ATCGTGAGAA CATGTACCGC 
TACCCCGACC AAGTATACTA CCGGCCAGTG GATCAGTACA GCAACCAGAA CAACTTTGTG 
CGTGACTGCG TCAACATCAC TGTCAAGCAG CACACAGTGA CCACCACCAC CAAGGGGGAG 
AACTTCACAG AGACCGACAT GAAGATCATG GAGCGTGTGG TGGAGCAGAT GTGTGTCACC 
CAGTACCAGA AGGAGTCCGA GGCTTACTAC CAAAGAGGGG CAAGCGCCAT CCTCTTCTCC 
CCGCCGCCTG TGATCCTCCT CATCTCGCTG CTCATTCTCT TGATAGTGGG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic predictions of prion disease susceptibility in carnivore species based on variability of the prion gene coding region.
PloS one7(12)e50623(2012)
Stewart P,Campbell L,Skogtvedt S,Griffin KA,Arnemo JM,Tryland M,Girling S,Miller MW,Tranulis MA,Goldmann W

Molecular dynamics studies on the structural stability of wild-type dog prion protein.
Journal of biomolecular structure & dynamics28(6)861-9(2011 Jun)
Zhang J,Liu DD

Polymorphisms of the prion protein gene (PRNP) in the Tibetan Mastiff.
Animal genetics40(6)1001-2(2009 Dec)
Zhang JE,Sun B,Pang WY,Qiao JW,Kouadir M,Yang LF,Zhao DM

Amino acid sequence of the Pekingese dog prion protein gene.
Xenotransplantation13(5)471-4(2006 Sep)
Wu C,Pang W,Yang J,Zhou X,Zhao D

Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein.
Journal of molecular biology289(5)1163-78(1999 Jun)
Wopfner F,Weidenh?fer G,Schneider R,von Brunn A,Gilch S,Schwarz TF,Werner T,Sch?tzl HM

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PRNP cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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