Gene Symbol | CLN5 |
Entrez Gene ID | 485498 |
Full Name | CLN5, intracellular trafficking protein |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » CLN5 cDNA ORF clone
Gene Symbol | CLN5 |
Entrez Gene ID | 485498 |
Full Name | CLN5, intracellular trafficking protein |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001011556.1 | NP_001011556.1 | ceroid-lipofuscinosis neuronal protein 5 precursor |
CLN5 | XP_001086029.2 | |
Mus musculus (house mouse) | Cln5 | NP_001028414.1 |
Gallus gallus (chicken) | CLN5 | XP_004938692.1 |
Danio rerio (zebrafish) | LOC100335010 | XP_002663389.1 |
Danio rerio (zebrafish) | cln5 | XP_697882.1 |
Xenopus tropicalis (tropical clawed frog) | cln5 | XP_002931974.2 |
Homo sapiens (human) | CLN5 | NP_006484.1 |
Bos taurus (cattle) | CLN5 | NP_001039764.1 |
Pan troglodytes (chimpanzee) | CLN5 | XP_509687.3 |
Canis lupus familiaris (dog) | CLN5 | NP_001011556.1 |
Rattus norvegicus (Norway rat) | Cln5 | NP_001178618.1 |
Rattus norvegicus (Norway rat) | RGD1564125 | XP_006232139.1 |
Golden Retriever dogs with neuronal ceroid lipofuscinosis have a two-base-pair deletion and frameshift in CLN5.
Gilliam D, Kolicheski A, Johnson GS, Mhlanga-Mutangadura T, Taylor JF, Schnabel RD, Katz ML
Molecular genetics and metabolism115(2-3)101-9(2015 Jun-Jul)
A mutation in canine CLN5 causes neuronal ceroid lipofuscinosis in Border collie dogs.
Melville SA, Wilson CL, Chiang CS, Studdert VP, Lingaas F, Wilton AN
Genomics86(3)287-94(2005 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Genome sequence from one affected dog, contained a plausibly causal homozygous mutation producing a frameshift and premature termination codon and encode a protein variant, which would lack 39 C-terminal amino acids in CLN5.
Title: Golden Retriever dogs with neuronal ceroid lipofuscinosis have a two-base-pair deletion and frameshift in CLN5.
Sequencing of CLN5 revealed a nonsense mutation (Q206X) within exon 4 that correlated with neuronal ceroid lipofuscinosis in Border collies
Title: A mutation in canine CLN5 causes neuronal ceroid lipofuscinosis in Border collie dogs.
The following CLN5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLN5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00142 | |
Clone ID Related Accession (Same CDS sequence) | NM_001011556.1 | |
Accession Version | NM_001011556.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Canis lupus familiaris(dog) | |
Product | ceroid-lipofuscinosis neuronal protein 5 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ875417.1. On Feb 5, 2005 this sequence version replaced XM_542617.1. ##Evidence-Data-START## Transcript exon combination :: AJ875417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGCAGG CGGGGAGCGC CGACCCCGGG GTCGGGGGCC ATTGGGCCGC GGGGCCTCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001011556.1 |
CDS | 51..1103 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001011556.1 |
1 | ATGGCGCAGG CGGGGAGCGC CGACCCCGGG GTCGGGGGCC ATTGGGCCGC GGGGCCTCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Golden Retriever dogs with neuronal ceroid lipofuscinosis have a two-base-pair deletion and frameshift in CLN5. |
A mutation in canine CLN5 causes neuronal ceroid lipofuscinosis in Border collie dogs. |