Gene Symbol | SLC9A1 |
Entrez Gene ID | 478171 |
Full Name | solute carrier family 9 member A1 |
Synonyms | NHE1 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » SLC9A1 cDNA ORF clone
Gene Symbol | SLC9A1 |
Entrez Gene ID | 478171 |
Full Name | solute carrier family 9 member A1 |
Synonyms | NHE1 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001287028.1 | NP_001273957.1 | sodium/hydrogen exchanger 1 |
Xenopus tropicalis (tropical clawed frog) | slc9a1 | XP_002934703.2 |
SLC9A1 | XP_001115213.2 | |
Bos taurus (cattle) | SLC9A1 | NP_777258.1 |
Rattus norvegicus (Norway rat) | Slc9a1 | NP_036784.1 |
Gallus gallus (chicken) | SLC9A1 | NP_001038108.1 |
Mus musculus (house mouse) | Slc9a1 | NP_058677.1 |
Homo sapiens (human) | SLC9A1 | NP_003038.2 |
Pan troglodytes (chimpanzee) | SLC9A1 | XP_513239.4 |
Canis lupus familiaris (dog) | SLC9A1 | XP_535345.2 |
Danio rerio (zebrafish) | slc9a1 | NP_001106952.1 |
High glucose concentration stimulates NHE-1 activity in distal nephron cells: the role of the Mek/Erk1/2/p90RSK and p38MAPK signaling pathways.
da Costa-Pessoa JM, Damasceno RS, Machado UF, Beloto-Silva O, Oliveira-Souza M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology33(2)333-43(2014)
Acidosis-mediated regulation of the NHE1 isoform of the Na?/H? exchanger in renal cells.
Odunewu A, Fliegel L
American journal of physiology. Renal physiology305(3)F370-81(2013 Aug)
Insulin increases acid production and may directly stimulate Na/H(+) exchange activity in cultured vascular smooth muscle cells.
Kahn AM, Yang M
Journal of vascular research48(6)505-12(2011)
Functional role of Na+-HCO3- cotransport in migration of transformed renal epithelial cells.
Schwab A, Rossmann H, Klein M, Dieterich P, Gassner B, Neff C, Stock C, Seidler U
The Journal of physiology568(Pt 2)445-58(2005 Oct)
Cell shrinkage activates Na+/H+ exchange in dog red cells by relieving inhibition of exchange by Na+ in isotonic medium.
Dunham PB
Blood cells, molecules & diseases32(3)389-93(2004 May-Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggested that extracellular high glucose stimulated NHE-1 acutely and chronically through Mek/Erk1/2/p90(RSK) and p38MAPK pathways, respectively.
Title: High glucose concentration stimulates NHE-1 activity in distal nephron cells: the role of the Mek/Erk1/2/p90RSK and p38MAPK signaling pathways.
in canine cells activation of NHE1 occurs through an ERK-dependent pathway affecting phosphorylation of a distinct set of amino acids in the cytosolic regulatory tail of NHE1
Title: Acidosis-mediated regulation of the NHE1 isoform of the Na?/H? exchanger in renal cells.
It is concluded that insulin stimulates acid accumulation in vascular smooth muscle cells that is normally effluxed by increased Na(+)/H(+) exchange activity.
Title: Insulin increases acid production and may directly stimulate Na/H(+) exchange activity in cultured vascular smooth muscle cells.
Erythrocyte shrinkage activates NHE1 by decreasing the apparent affinity for Na+ at the inhibitory sites. Shrinkage has no effect on the apparent affinity for Na+ at the substrate sites for activation of NHE1.
Title: Cell shrinkage activates Na+/H+ exchange in dog red cells by relieving inhibition of exchange by Na+ in isotonic medium.
The following SLC9A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC9A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00449 | |
Clone ID Related Accession (Same CDS sequence) | NM_001287028.1 | |
Accession Version | NM_001287028.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2451bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-03-27 | |
Organism | Canis lupus familiaris(dog) | |
Product | sodium/hydrogen exchanger 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03001717.1. On Nov 23, 2013 this sequence version replaced XM_535345.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments and orthologous data. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## |
1 | ATGCTGCTTC TGTGGTCTGG CATCTGCCGC CGCGCTCCTC CGCGAATCTT CCCTTCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001273957.1 |
CDS | 805..3255 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001287028.1 |
1 | ATGCTGCTTC TGTGGTCTGG CATCTGCCGC CGCGCTCCTC CGCGAATCTT CCCTTCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
High glucose concentration stimulates NHE-1 activity in distal nephron cells: the role of the Mek/Erk1/2/p90RSK and p38MAPK signaling pathways. |
Acidosis-mediated regulation of the NHE1 isoform of the Na?/H? exchanger in renal cells. |
Insulin increases acid production and may directly stimulate Na/H(+) exchange activity in cultured vascular smooth muscle cells. |
Functional role of Na+-HCO3- cotransport in migration of transformed renal epithelial cells. |
Cell shrinkage activates Na+/H+ exchange in dog red cells by relieving inhibition of exchange by Na+ in isotonic medium. |