Gene Symbol | CYP2C18 |
Entrez Gene ID | 415122 |
Full Name | cytochrome P450 2C21 |
Synonyms | CYP2C19,CYP2C21,CYPIIC21 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » CYP2C18 cDNA ORF clone
Gene Symbol | CYP2C18 |
Entrez Gene ID | 415122 |
Full Name | cytochrome P450 2C21 |
Synonyms | CYP2C19,CYP2C21,CYPIIC21 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001197044.1 | NP_001183973.1 | cytochrome P450 2C21 |
CYP2C75 | NP_001035301.1 | |
Bos taurus (cattle) | LOC522146 | XP_002698447.1 |
Bos taurus (cattle) | LOC785540 | XP_005225701.1 |
Homo sapiens (human) | CYP2C19 | NP_000760.1 |
Pan troglodytes (chimpanzee) | LOC740956 | XP_001152464.1 |
Bos taurus (cattle) | CYP2C19 | NP_001103262.1 |
Rattus norvegicus (Norway rat) | Cyp2c6v1 | NP_001013926.1 |
Canis lupus familiaris (dog) | CYP2C18 | NP_001183973.1 |
A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Locuson CW, Alfaro JF, Zaya MJ, Billen D, White JA, Jones JP
Drug metabolism letters5(4)253-8(2011 Dec)
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Mega JL, Close SL, Wiviott SD, Shen L, Walker JR, Simon T, Antman EM, Braunwald E, Sabatine MS
Lancet (London, England)376(9749)1312-9(2010 Oct)
Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450.
Shou M, Norcross R, Sandig G, Lu P, Li Y, Lin Y, Mei Q, Rodrigues AD, Rushmore TH
Drug metabolism and disposition: the biological fate of chemicals31(9)1161-9(2003 Sep)
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
Blaisdell J, Goldstein JA, Bai SA
Drug metabolism and disposition: the biological fate of chemicals26(3)278-83(1998 Mar)
Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs.
Uchida T, Komori M, Kitada M, Kamataki T
Molecular pharmacology38(5)644-51(1990 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Report a non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Title: A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
In acute coronary syndromes who have percutaneous intervention, when both ABCB1 and CYP2C19 are taken into account this genotype associated with increased risk of major adverse cardiovascular events while on standard doses of clopidogrel.
Title: Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
The following CYP2C18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP2C18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00408 | |
Clone ID Related Accession (Same CDS sequence) | NM_001197044.1 | |
Accession Version | NM_001197044.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Canis lupus familiaris(dog) | |
Product | cytochrome P450 2C21 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03015430.1. On or before Oct 3, 2010 this sequence version replaced XM_854406.1, XM_854444.1, XM_534973.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF049909.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00013515, SAMN07419817 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATCTCT TCATAGTTCT GGTGATATGT CTTTCTTGTT TGATTTCTTT CTTTCTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001183973.1 |
CDS | 12..1484 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001197044.1 |
1 | ATGGATCTCT TCATAGTTCT GGTGATATGT CTTTCTTGTT TGATTTCTTT CTTTCTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21. |
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. |
Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450. |
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression. |
Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs. |