IL1B cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL1B
Entrez Gene ID	403974
Full Name	interleukin 1 beta
Synonyms	IL-1
General protein information	Preferred Names interleukin 1 beta Names interleukin-1 beta IL-1 beta interleukin-1 beta proprotein
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
XM_022404323.1	XP_022260031.1	interleukin-1 beta isoform X1
NM_001037971.1	NP_001033060.1	interleukin-1 beta
XM_005630074.1	XP_005630131.1	interleukin-1 beta isoform X1
XM_005630074.2	XP_005630131.1	interleukin-1 beta isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL1B	NP_000567.1
Canis lupus familiaris (dog)	IL1B	NP_001033060.1
Mus musculus (house mouse)	Il1b	NP_032387.1
Bos taurus (cattle)	IL1B	NP_776518.1
Rattus norvegicus (Norway rat)	Il1b	NP_113700.2
	IL1B	NP_001036221.1
Pan troglodytes (chimpanzee)	IL1B	XP_001147075.1
Xenopus tropicalis (tropical clawed frog)	il1b	XP_002932618.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and Function of Interleukin-1?-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells.
Konno T, Nakano R, Mamiya R, Tsuchiya H, Kitanaka T, Namba S, Kitanaka N, Okabayashi K, Narita T, Sugiya H
PloS one11(11)e0166707(2016)

Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.
Maissen-Villiger CA, Schweighauser A, van Dorland HA, Morel C, Bruckmaier RM, Zurbriggen A, Francey T
PloS one11(1)e0148029(2016)

Activation of MEK/ERK pathways through NF-?B activation is involved in interleukin-1?-induced cyclooxygenease-2 expression in canine dermal fibroblasts.
Tsuchiya H, Nakano R, Konno T, Okabayashi K, Narita T, Sugiya H
Veterinary immunology and immunopathology168(3-4)223-32(2015 Dec)

Anti-inflammatory properties and expression in selected organs of canine interleukin-1? splice variant 1.
Kiczak L, Wa?ecka-Zacharska E, Bania J, Sambor I, Stefaniak T, Dzi?giel P, Zacharski M, Tomaszek A, Rybi?ska I, Pas?awska U
Veterinary immunology and immunopathology167(3-4)91-5(2015 Oct)

The early inflammatory response after flexor tendon healing: a gene expression and histological analysis.
Manning CN, Havlioglu N, Knutsen E, Sakiyama-Elbert SE, Silva MJ, Thomopoulos S, Gelberman RH
Journal of orthopaedic research : official publication of the Orthopaedic Research Society32(5)645-52(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the regulation of the expression and function of NGAL in IL-1beta-treated Madin-Darby canine kidney (MDCK) cells, was investigated.
Title: Expression and Function of Interleukin-1?-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells.

Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression.
Title: Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.

These findings suggest that stimulation of MEK/ERK signaling pathway by NF-kappaB activation regulates IL-1beta-induced COX-2 expression and subsequent prostaglandin E2 release in canine dermal fibroblasts.
Title: Activation of MEK/ERK pathways through NF-?B activation is involved in interleukin-1?-induced cyclooxygenease-2 expression in canine dermal fibroblasts.

IL-1beta splice variant 1 (IL-1betasv1) was significantly up-regulated in failing myocardium of dogs suffering from chronic degenerative valvular disease
Title: Anti-inflammatory properties and expression in selected organs of canine interleukin-1? splice variant 1.

after flexor tendon injury, a greater than 4,000-fold up-regulation in the expression of IL-1beta was observed
Title: The early inflammatory response after flexor tendon healing: a gene expression and histological analysis.

The following IL1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe00401	NM_001037971.1 Latest version!	Canis lupus familiaris interleukin 1 beta (IL1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe00401	XM_022404323.1 Latest version!	Canis lupus familiaris interleukin 1 beta (IL1B), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe00401	XM_005630074.2 Latest version!	Canis lupus familiaris interleukin 1 beta (IL1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
View Old Accession Versions >>
OCe00401	XM_005630074.1	Canis lupus familiaris interleukin 1, beta (IL1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL1B ( NM_001037971.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001033060.1 Canis lupus familiaris interleukin 1 beta (IL1B), mRNA.

Price & Availability↑

CloneID	OCe00401
Clone ID Related Accession (Same CDS sequence)	XM_022404323.1 , NM_001037971.1 , XM_005630074.1 , XM_005630074.2
Accession Version	NM_001037971.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Canis lupus familiaris(dog)
Product	interleukin-1 beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ251036.1. On Dec 24, 2005 this sequence version replaced XM_849577.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ251036.1, EU249360.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001033060.1
CDS	1..798
Translation	MAAVPELTSEMMAYSSNNENDLFFEADGPGNVKCCCQDLNHSSLVDEGIQLQVSHQLCNKSLRHFVSVIVALEKLKKPCPQVLQEDDLKSIFCYIFEEEPIICKTDADNFMSDAAMQSVDCKLQDISHKYLVLSNSYELRALHLNGENVNKQVVFHMSFVHGDESNNKIPVVLGIKQKNLYLSCVMKDGKPTLQLEKVDPKVYPKRKMEKRFVFNKIEIKNTVEFESSQYPNWYISTSQVEGMPVFLGNTRGGQDITDFTMEFSS

Target ORF information:

RefSeq Version	NM_001037971.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 1 beta (IL1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037971.1

ORF Insert Sequence:

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL1B ( XM_022404323.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_022260031.1 Canis lupus familiaris interleukin 1 beta (IL1B), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe00401
Clone ID Related Accession (Same CDS sequence)	XM_022404323.1 , NM_001037971.1 , XM_005630074.1 , XM_005630074.2
Accession Version	XM_022404323.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	interleukin-1 beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006599.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_022260031.1
CDS	219..1016
Translation	MAAVPELTSEMMAYSSNNENDLFFEADGPGNVKCCCQDLNHSSLVDEGIQLQVSHQLCNKSLRHFVSVIVALEKLKKPCPQVLQEDDLKSIFCYIFEEEPIICKTDADNFMSDAAMQSVDCKLQDISHKYLVLSNSYELRALHLNGENVNKQVVFHMSFVHGDESNNKIPVVLGIKQKNLYLSCVMKDGKPTLQLEKVDPKVYPKRKMEKRFVFNKIEIKNTVEFESSQYPNWYISTSQVEGMPVFLGNTRGGQDITDFTMEFSS

Target ORF information:

RefSeq Version	XM_022404323.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 1 beta (IL1B), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_022404323.1

ORF Insert Sequence:

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL1B ( XM_005630074.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005630131.1 Canis lupus familiaris interleukin 1, beta (IL1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe00401
Clone ID Related Accession (Same CDS sequence)	XM_022404323.1 , NM_001037971.1 , XM_005630074.1 , XM_005630074.2
Accession Version	XM_005630074.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	interleukin-1 beta isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726089.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005630131.1
CDS	165..962
Translation	MAAVPELTSEMMAYSSNNENDLFFEADGPGNVKCCCQDLNHSSLVDEGIQLQVSHQLCNKSLRHFVSVIVALEKLKKPCPQVLQEDDLKSIFCYIFEEEPIICKTDADNFMSDAAMQSVDCKLQDISHKYLVLSNSYELRALHLNGENVNKQVVFHMSFVHGDESNNKIPVVLGIKQKNLYLSCVMKDGKPTLQLEKVDPKVYPKRKMEKRFVFNKIEIKNTVEFESSQYPNWYISTSQVEGMPVFLGNTRGGQDITDFTMEFSS

Target ORF information:

RefSeq Version	XM_005630074.1
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris interleukin 1, beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005630074.1

ORF Insert Sequence:

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL1B ( XM_005630074.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005630131.1 Canis lupus familiaris interleukin 1 beta (IL1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe00401
Clone ID Related Accession (Same CDS sequence)	XM_022404323.1 , NM_001037971.1 , XM_005630074.1 , XM_005630074.2
Accession Version	XM_005630074.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	interleukin-1 beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006599.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005630074.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005630131.1
CDS	1397..2194
Translation	MAAVPELTSEMMAYSSNNENDLFFEADGPGNVKCCCQDLNHSSLVDEGIQLQVSHQLCNKSLRHFVSVIVALEKLKKPCPQVLQEDDLKSIFCYIFEEEPIICKTDADNFMSDAAMQSVDCKLQDISHKYLVLSNSYELRALHLNGENVNKQVVFHMSFVHGDESNNKIPVVLGIKQKNLYLSCVMKDGKPTLQLEKVDPKVYPKRKMEKRFVFNKIEIKNTVEFESSQYPNWYISTSQVEGMPVFLGNTRGGQDITDFTMEFSS

Target ORF information:

RefSeq Version	XM_005630074.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris interleukin 1 beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005630074.2

ORF Insert Sequence:

ATGGCAGCAG TACCCGAACT CACCAGTGAA ATGATGGCTT ACTCCAGTAA CAATGAGAAT 
GACCTATTCT TTGAAGCTGA TGGCCCTGGA AATGTGAAGT GCTGCTGCCA AGACCTGAAC 
CACAGTTCTC TGGTAGATGA GGGCATCCAG TTGCAAGTCT CCCACCAGCT CTGTAACAAG 
AGTCTGAGGC ATTTCGTGTC AGTCATTGTA GCTTTGGAGA AGCTGAAGAA GCCCTGCCCA 
CAGGTCCTCC AGGAGGATGA CCTGAAGAGC ATCTTTTGCT ACATCTTTGA AGAAGAACCT 
ATCATCTGCA AAACAGATGC GGATAATTTT ATGAGTGATG CAGCCATGCA ATCGGTGGAC 
TGCAAGTTAC AGGACATAAG CCACAAATAC CTGGTGCTGT CTAACTCATA TGAGCTTCGG 
GCTCTCCACC TCAATGGGGA AAATGTGAAC AAACAAGTGG TGTTCCACAT GAGCTTTGTG 
CACGGGGATG AAAGTAATAA CAAGATACCT GTGGTCTTGG GCATCAAACA AAAGAATCTG 
TACCTGTCCT GTGTGATGAA GGATGGAAAG CCCACCCTAC AGCTAGAGAA GGTAGACCCC 
AAAGTCTACC CAAAGAGGAA GATGGAAAAG CGATTTGTCT TCAACAAGAT AGAAATCAAG 
AACACAGTGG AATTTGAGTC TTCTCAGTAC CCTAACTGGT ACATCAGCAC CTCTCAAGTC 
GAAGGAATGC CTGTCTTCCT AGGAAATACC AGAGGTGGCC AGGATATAAC TGACTTCACC 
ATGGAATTCT CTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and Function of Interleukin-1?-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells.
PloS one11(11)e0166707(2016)
Konno T,Nakano R,Mamiya R,Tsuchiya H,Kitanaka T,Namba S,Kitanaka N,Okabayashi K,Narita T,Sugiya H

Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.
PloS one11(1)e0148029(2016)
Maissen-Villiger CA,Schweighauser A,van Dorland HA,Morel C,Bruckmaier RM,Zurbriggen A,Francey T

Activation of MEK/ERK pathways through NF-?B activation is involved in interleukin-1?-induced cyclooxygenease-2 expression in canine dermal fibroblasts.
Veterinary immunology and immunopathology168(3-4)223-32(2015 Dec)
Tsuchiya H,Nakano R,Konno T,Okabayashi K,Narita T,Sugiya H

Anti-inflammatory properties and expression in selected organs of canine interleukin-1? splice variant 1.
Veterinary immunology and immunopathology167(3-4)91-5(2015 Oct)
Kiczak L,Wa?ecka-Zacharska E,Bania J,Sambor I,Stefaniak T,Dzi?giel P,Zacharski M,Tomaszek A,Rybi?ska I,Pas?awska U

The early inflammatory response after flexor tendon healing: a gene expression and histological analysis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society32(5)645-52(2014 May)
Manning CN,Havlioglu N,Knutsen E,Sakiyama-Elbert SE,Silva MJ,Thomopoulos S,Gelberman RH

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IL1B cDNA ORF clone, Canis lupus familiaris(dog)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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