Gene Symbol | RAC1 |
Entrez Gene ID | 403955 |
Full Name | Rac family small GTPase 1 |
Synonyms | RAC2 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » RAC1 cDNA ORF clone
Gene Symbol | RAC1 |
Entrez Gene ID | 403955 |
Full Name | Rac family small GTPase 1 |
Synonyms | RAC2 |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
XM_005621021.1 | XP_005621078.1 | ras-related C3 botulinum toxin substrate 1 isoform X1 |
XM_022419478.1 | XP_022275186.1 | ras-related C3 botulinum toxin substrate 1 isoform X2 |
NM_001003274.2 | NP_001003274.1 | ras-related C3 botulinum toxin substrate 1 precursor |
Canis lupus familiaris (dog) | RAC1 | NP_001003274.1 |
Bos taurus (cattle) | RAC1 | NP_776588.1 |
Danio rerio (zebrafish) | rac1a | NP_956065.1 |
Drosophila melanogaster (fruit fly) | Rac2 | NP_001261517.1 |
LOC717755 | XP_001109586.2 | |
Mus musculus (house mouse) | Rac1 | NP_033033.1 |
Drosophila melanogaster (fruit fly) | Rac1 | NP_476950.1 |
Arabidopsis thaliana (thale cress) | ROP1 | NP_190698.1 |
Arabidopsis thaliana (thale cress) | RAC6 | NP_195320.1 |
Xenopus tropicalis (tropical clawed frog) | rac1 | NP_001004840.1 |
Rattus norvegicus (Norway rat) | Rac1 | NP_599193.1 |
Gallus gallus (chicken) | RAC1 | NP_990348.1 |
Pan troglodytes (chimpanzee) | RAC1 | NP_001233310.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005445 | XP_315449.4 |
Homo sapiens (human) | RAC1 | NP_061485.1 |
Arabidopsis thaliana (thale cress) | ARAC1 | NP_179371.1 |
Oryza sativa (rice) | Os02g0120800 | NP_001045712.1 |
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Raya-Sandino A, Castillo-Kauil A, Dom?nguez-Calder?n A, Alarc?n L, Flores-Benitez D, Cuellar-Perez F, L?pez-Bayghen B, Ch?vez-Mungu?a B, V?zquez-Prado J, Gonz?lez-Mariscal L
Biochimica et biophysica acta1864(10)1714-1733(2017 10)
Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells.
Gopal SK, Greening DW, Hanssen EG, Zhu HJ, Simpson RJ, Mathias RA
Oncotarget7(15)19709-22(2016 Apr)
Insufficient ability of Rac1b to perturb cystogenesis.
Mori Y, Yagi S, Sakurai A, Matsuda M, Kiyokawa E
Small GTPases4(1)9-15(2013 Jan-Mar)
Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment.
Monteleon CL, Sedgwick A, Hartsell A, Dai M, Whittington C, Voytik-Harbin S, D'Souza-Schorey C
Molecular biology of the cell23(23)4495-505(2012 Dec)
Rapid suppression of activated Rac1 by cadherins and nectins during de novo cell-cell adhesion.
Kitt KN, Nelson WJ
PloS one6(3)e17841(2011 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation.
Title: Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Data indicate exosomal Rac1/PAK2 as angiogenic promoters.
Title: Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells.
This inversion of glandular orientation is accompanied by Rac1 inactivation during early cystogenesis, and temporal activation of Rac1 is sufficient to recover the normal cyst phenotype.
Title: Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment.
These results indicate that cadherins and nectins cooperate to induce and then rapidly suppress Rac1 activity during initial cell-cell adhesion.
Title: Rapid suppression of activated Rac1 by cadherins and nectins during de novo cell-cell adhesion.
Numb acts to suppress Rac1-GTP accumulation, and its loss leads to increased sensitivity toward extracellular signals that disrupt cell-cell adhesion to induce epithelial-mesenchymal transition (EMT) and cell dispersal
Title: Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation.
The following RAC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00144 | |
Clone ID Related Accession (Same CDS sequence) | NM_001003274.2 | |
Accession Version | NM_001003274.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-06 | |
Organism | Canis lupus familiaris(dog) | |
Product | ras-related C3 botulinum toxin substrate 1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X56390.1. On Sep 15, 2005 this sequence version replaced NM_001003274.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X56390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCAGGCCA TCAAGTGTGT GGTGGTGGGA GACGGAGCTG TAGGTAAAAC TTGTCTACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001003274.1 |
CDS | 1..579 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001003274.2 |
1 | ATGCAGGCCA TCAAGTGTGT GGTGGTGGGA GACGGAGCTG TAGGTAAAAC TTGTCTACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe07502 | |
Clone ID Related Accession (Same CDS sequence) | XM_005621021.1 | |
Accession Version | XM_005621021.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | ras-related C3 botulinum toxin substrate 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006588.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGGCCA TCAAGTGTGT GGTGGTGGAA GACGGAGCTG TAGGTAAAAC TTGTCTACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005621078.1 |
CDS | 4..639 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005621021.1 |
1 | ATGCAGGCCA TCAAGTGTGT GGTGGTGGAA GACGGAGCTG TAGGTAAAAC TTGTCTACTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe288666 | |
Clone ID Related Accession (Same CDS sequence) | XM_022419478.1 | |
Accession Version | XM_022419478.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | ras-related C3 botulinum toxin substrate 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006588.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGTGTG GGAGAGCTGT AGGTAAAACT TGTCTACTGA TCAGTTACAC AACCAATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022275186.1 |
CDS | 16..630 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022419478.1 |
1 | ATGGTGTGTG GGAGAGCTGT AGGTAAAACT TGTCTACTGA TCAGTTACAC AACCAATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. |
Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells. |
Insufficient ability of Rac1b to perturb cystogenesis. |
Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment. |
Rapid suppression of activated Rac1 by cadherins and nectins during de novo cell-cell adhesion. |