Gene Symbol | CDKN2A |
Entrez Gene ID | 100271861 |
Full Name | cyclin dependent kinase inhibitor 2A |
Synonyms | INK4a,p14ARF,p16,p16INK4A |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » CDKN2A cDNA ORF clone
Gene Symbol | CDKN2A |
Entrez Gene ID | 100271861 |
Full Name | cyclin dependent kinase inhibitor 2A |
Synonyms | INK4a,p14ARF,p16,p16INK4A |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
XM_014117791.1 | XP_013973266.1 | cyclin-dependent kinase inhibitor 2A |
LOC709988 | XP_001098554.1 | |
Danio rerio (zebrafish) | LOC100329528 | XP_002660514.1 |
Xenopus tropicalis (tropical clawed frog) | cdkn2b | NP_001006920.1 |
Canis lupus familiaris (dog) | CDKN2A | XP_003431646.2 |
Pan troglodytes (chimpanzee) | CDKN2A | NP_001139762.1 |
Bos taurus (cattle) | CDKN2A | XP_002689593.3 |
Mus musculus (house mouse) | Cdkn2a | NP_001035744.1 |
Rattus norvegicus (Norway rat) | Cdkn2a | NP_113738.1 |
Homo sapiens (human) | CDKN2A | NP_000068.1 |
The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer.
Shearin AL, Hedan B, Cadieu E, Erich SA, Schmidt EV, Faden DL, Cullen J, Abadie J, Kwon EM, Gr?ne A, Devauchelle P, Rimbault M, Karyadi DM, Lynch M, Galibert F, Breen M, Rutteman GR, Andr? C, Parker HG, Ostrander EA
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology21(7)1019-27(2012 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
no significant difference in expression between human papillomavirus-positive and -negative Bowen disease
Title: Human papillomavirus infection in Bowen disease: negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease.
This study revealed the inactivation of p16 gene through hypermethylation of its CpG island in a fraction of canine lymphoid tumor cells.
Title: Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells.
In lipomas, the increase of HMGA2 due to 12q14-15 chromosomal rearrangements is accompanied by an increased expression of p14Arf.
Title: Permanent activation of HMGA2 in lipomas mimics its temporal physiological activation linked to the gain of adipose tissue.
The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors.
Title: Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.
In this study, the full-length complementary DNA (cDNA) of the canine p16 gene was cloned using the 5' and 3' rapid amplification of cDNA ends methods.
Title: Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.
The following CDKN2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe39171 | |
Clone ID Related Accession (Same CDS sequence) | XM_014117791.1 | |
Accession Version | XM_014117791.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | cyclin-dependent kinase inhibitor 2A | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006593.3) and transcript sequence (JN086563.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## assembly gap :: added 214 transcript bases to patch genome assembly gap ##RefSeq-Attributes-END## |
1 | ATGGAGCCCT TCGCCGACTG GCTGGCCTCG GCGGCAGCCC GGGGCCGCGC GGACGAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_013973266.1 |
CDS | 89..544 |
Translation |
Target ORF information:
Target ORF information:
|
XM_014117791.1 |
1 | ATGGAGCCCT TCGCCGACTG GCTGGCCTCG GCGGCAGCCC GGGGCCGCGC GGACGAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. |