gpx2 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	gpx2
Entrez Gene ID	100334384
Full Name	glutathione peroxidase 2
Synonyms	si:ch73-199k24.2
General protein information	Preferred Names glutathione peroxidase 2 Names glutathione peroxidase 2 glutathione peroxidase 2 (gastrointestinal)
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001329759.1	NP_001316688.1	glutathione peroxidase 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish.
Erickson T, Nicolson T
BMC genomics16842(2015 Oct)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.
Briolat V, Jouneau L, Carvalho R, Palha N, Langevin C, Herbomel P, Schwartz O, Spaink HP, Levraud JP, Boudinot P
Journal of immunology (Baltimore, Md. : 1950)192(9)4328-41(2014 May)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following gpx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the gpx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa49954	NM_001329759.1 Latest version!	Danio rerio glutathione peroxidase 2 (gpx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

gpx2 ( NM_001329759.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001316688.1 Danio rerio glutathione peroxidase 2 (gpx2), mRNA.

Price & Availability↑

CloneID	ODa49954
Clone ID Related Accession (Same CDS sequence)	NM_001329759.1
Accession Version	NM_001329759.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-07
Organism	Danio rerio(zebrafish)
Product	glutathione peroxidase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CU855484.5. On Jul 27, 2016 this sequence version replaced XM_009293291.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END##

ATGACGTTCA TAGCGAAGAC TTTTTATGAT CTGCACGCAA CTACTCTGGA AGGGGACACC 
ATAGACTTTA ATATTTACCG GGGAAGAGTG GTGCTAATTG AGAATGTGGC CTCGCTGTGA 
GGGACGACCA CCCAGGACTA CACGCAGCTT AATGAGCTCC AGAGCAGATA TCCTCATCGG 
CTTGTAGTCC TGGGCTTTCC CTGCAACCAG TTTGGATACC AGGAGAACTG CTCTGATGGA 
GAAATTCTTA ATTCCTTAAA GTATGTTCGT CCAGGTGAAG GGTATAAGCC TTCGTTCACT 
ATTTTTCAGA AGTGCGTTGT AAACGGGAGT GATGCGCATC CTGTCTTTTC CTACTTAAAA 
GACAAGCTCC CTTATCCAGA CGATGACCCT GTGACTTTAA TTCAAGACCC TAAATATCTA 
GTCTGGAATC CAGTCAGTCG AAATGATATT TCGTGGAATT TTGAAAAGTT TTTAATTGGG 
CCAGAAGGCG AGCCCTTCAA AAGATACAGT AAGAAGTTTC AAACGATCAA TATTGAACCT 
GACATTCAAA GGCTACTGAA GCTGACCAAG AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316688.1
CDS	14..589
Translation	MTFIAKTFYDLHATTLEGDTIDFNIYRGRVVLIENVASL*GTTTQDYTQLNELQSRYPHRLVVLGFPCNQFGYQENCSDGEILNSLKYVRPGEGYKPSFTIFQKCVVNGSDAHPVFSYLKDKLPYPDDDPVTLIQDPKYLVWNPVSRNDISWNFEKFLIGPEGEPFKRYSKKFQTINIEPDIQRLLKLTKN

Target ORF information:

RefSeq Version	NM_001329759.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio glutathione peroxidase 2 (gpx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329759.1

ORF Insert Sequence:

ATGACGTTCA TAGCGAAGAC TTTTTATGAT CTGCACGCAA CTACTCTGGA AGGGGACACC 
ATAGACTTTA ATATTTACCG GGGAAGAGTG GTGCTAATTG AGAATGTGGC CTCGCTGTGA 
GGGACGACCA CCCAGGACTA CACGCAGCTT AATGAGCTCC AGAGCAGATA TCCTCATCGG 
CTTGTAGTCC TGGGCTTTCC CTGCAACCAG TTTGGATACC AGGAGAACTG CTCTGATGGA 
GAAATTCTTA ATTCCTTAAA GTATGTTCGT CCAGGTGAAG GGTATAAGCC TTCGTTCACT 
ATTTTTCAGA AGTGCGTTGT AAACGGGAGT GATGCGCATC CTGTCTTTTC CTACTTAAAA 
GACAAGCTCC CTTATCCAGA CGATGACCCT GTGACTTTAA TTCAAGACCC TAAATATCTA 
GTCTGGAATC CAGTCAGTCG AAATGATATT TCGTGGAATT TTGAAAAGTT TTTAATTGGG 
CCAGAAGGCG AGCCCTTCAA AAGATACAGT AAGAAGTTTC AAACGATCAA TATTGAACCT 
GACATTCAAA GGCTACTGAA GCTGACCAAG AACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish.
BMC genomics16842(2015 Oct)
Erickson T,Nicolson T

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.
Journal of immunology (Baltimore, Md. : 1950)192(9)4328-41(2014 May)
Briolat V,Jouneau L,Carvalho R,Palha N,Langevin C,Herbomel P,Schwartz O,Spaink HP,Levraud JP,Boudinot P

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

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gpx2 cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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