Gene Symbol | sir-2.1 |
Entrez Gene ID | 177924 |
Full Name | NAD-dependent protein deacetylase sir-2.1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » sir-2.1 cDNA ORF clone
Gene Symbol | sir-2.1 |
Entrez Gene ID | 177924 |
Full Name | NAD-dependent protein deacetylase sir-2.1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001268555.2 | NP_001255484.1 | NAD-dependent protein deacetylase sir-2.1 |
NM_001268555.1 | NP_001255484.1 | NAD-dependent protein deacetylase sir-2.1 |
NM_001268556.1 | NP_001255485.1 | NAD-dependent protein deacetylase sir-2.1 |
NM_001268556.2 | NP_001255485.1 | Deacetylase sirtuin-type domain-containing protein |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
SIRT1 plays essential roles in cell survival, inflammation, energy metabolism, and aging.
Title: The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1.
Sir-2.1; dnj-14 double mutants showed full lifespan rescue by resveratrol.
Title: Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.
Prolongation of survival under glucose exposure by quercetin is dependent on SIR-2.1, DAF-12, and MDT-15
Title: The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.
The authors show that the mating circuits' functional durability depends on the metabolic regulator SIR-2.1, a NAD(+)-dependent histone deacetylase.
Title: SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans.
C. elegans produces specific small molecules to control adult lifespan in a SIR-2.1-dependent manner.
Title: Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1.
The following sir-2.1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the sir-2.1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa342792 | |
Clone ID Related Accession (Same CDS sequence) | NM_001268556.1 , NM_001268556.2 | |
Accession Version | NM_001268556.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | NAD-dependent protein deacetylase sir-2.1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). COMPLETENESS: incomplete on both ends. |
1 | ATGCACATTA CACAAGAAAC AGATATTTCC GATGCACCCG AAACAAACAC AGATTCGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001255485.1 |
CDS | 1..1734 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001268556.1 |
1 | ATGCACATTA CACAAGAAAC AGATATTTCC GATGCACCCG AAACAAACAC AGATTCGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa342792 | |
Clone ID Related Accession (Same CDS sequence) | NM_001268556.1 , NM_001268556.2 | |
Accession Version | NM_001268556.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Deacetylase sirtuin-type domain-containing protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Sep 4, 2019 this sequence version replaced NM_001268556.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGCACATTA CACAAGAAAC AGATATTTCC GATGCACCCG AAACAAACAC AGATTCGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001255485.1 |
CDS | 1..1734 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001268556.2 |
1 | ATGCACATTA CACAAGAAAC AGATATTTCC GATGCACCCG AAACAAACAC AGATTCGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa344673 | |
Clone ID Related Accession (Same CDS sequence) | NM_001268555.2 , NM_001268555.1 | |
Accession Version | NM_001268555.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | NAD-dependent protein deacetylase sir-2.1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). On Sep 4, 2019 this sequence version replaced NM_001268555.1. |
1 | ATGTCACGTG ATAGTGGCAA CGATTCAGAA GTTGCGGTCA CACACGGGGA AGTGCAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001255484.1 |
CDS | 62..1885 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001268555.2 |
1 | ATGTCACGTG ATAGTGGCAA CGATTCAGAA GTTGCGGTCA CACACGGGGA AGTGCAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa344673 | |
Clone ID Related Accession (Same CDS sequence) | NM_001268555.2 , NM_001268555.1 | |
Accession Version | NM_001268555.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1824bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | NAD-dependent protein deacetylase sir-2.1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003282). COMPLETENESS: incomplete on both ends. |
1 | ATGTCACGTG ATAGTGGCAA CGATTCAGAA GTTGCGGTCA CACACGGGGA AGTGCAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001255484.1 |
CDS | 1..1824 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001268555.1 |
1 | ATGTCACGTG ATAGTGGCAA CGATTCAGAA GTTGCGGTCA CACACGGGGA AGTGCAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |