Gene Symbol | mec-12 |
Entrez Gene ID | 175419 |
Full Name | Detyrosinated tubulin alpha-3 chain |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » mec-12 cDNA ORF clone
Gene Symbol | mec-12 |
Entrez Gene ID | 175419 |
Full Name | Detyrosinated tubulin alpha-3 chain |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_065262.5 | NP_497663.1 | Detyrosinated tubulin alpha-3 chain |
NM_065262.6 | NP_497663.1 | Detyrosinated tubulin alpha-3 chain |
Homo sapiens (human) | TUBA3E | NP_997195.1 |
Rattus norvegicus (Norway rat) | Tuba3a | NP_001035097.1 |
Drosophila melanogaster (fruit fly) | alphaTub85E | NP_524297.1 |
Caenorhabditis elegans (roundworm) | mec-12 | NP_497663.1 |
Canis lupus familiaris (dog) | LOC477570 | XP_534765.2 |
Mus musculus (house mouse) | Tuba3a | NP_033472.1 |
Rattus norvegicus (Norway rat) | Tuba3b | NP_001019507.1 |
Gallus gallus (chicken) | LOC425049 | XP_422851.1 |
Danio rerio (zebrafish) | LOC795591 | XP_003198796.1 |
Xenopus tropicalis (tropical clawed frog) | tuba3c | NP_001015934.1 |
Mus musculus (house mouse) | Tuba3b | NP_033475.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001218 | XP_551626.4 |
Canis lupus familiaris (dog) | LOC608051 | XP_849904.1 |
Bos taurus (cattle) | TUBA3E | XP_002694727.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001219 | XP_321937.5 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
tubulin acetylation and microtubule protofilaments were unaffected in the mec-12(gm379) mutant. We hypothesize that the G416E substitution may alter the association of microtubule-binding proteins with microtubules
Title: Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans.
Acetylation of MEC-12 alpha-tubulin constrains protofilament number in C. elegans touch receptor neurons.
Title: Posttranslational acetylation of ?-tubulin constrains protofilament number in native microtubules.
Data show that all mec-15 phenotypes can be dominantly suppressed by mutations in mec-7, which encodes a beta-tubulin, and dominantly enhanced by mutations in mec-12, which encodes an alpha-tubulin.
Title: mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development.
The following mec-12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mec-12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa341269 | |
Clone ID Related Accession (Same CDS sequence) | NM_065262.5 , NM_065262.6 | |
Accession Version | NM_065262.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Detyrosinated tubulin alpha-3 chain | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_065262.4. COMPLETENESS: incomplete on both ends. |
1 | ATGAGAGAAG TAATTTCGAT TCACATCGGA CAAGCCGGAG TCCAAATCGG AAATGCTTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_497663.1 |
CDS | 1..1353 |
Translation |
Target ORF information:
Target ORF information:
|
NM_065262.5 |
1 | ATGAGAGAAG TAATTTCGAT TCACATCGGA CAAGCCGGAG TCCAAATCGG AAATGCTTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341269 | |
Clone ID Related Accession (Same CDS sequence) | NM_065262.5 , NM_065262.6 | |
Accession Version | NM_065262.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Detyrosinated tubulin alpha-3 chain | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_065262.5. |
1 | ATGAGAGAAG TAATTTCGAT TCACATCGGA CAAGCCGGAG TCCAAATCGG AAATGCTTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_497663.1 |
CDS | 101..1453 |
Translation |
Target ORF information:
Target ORF information:
|
NM_065262.6 |
1 | ATGAGAGAAG TAATTTCGAT TCACATCGGA CAAGCCGGAG TCCAAATCGG AAATGCTTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |