Gene Symbol | apn-1 |
Entrez Gene ID | 174291 |
Full Name | DNA-(apurinic or apyrimidinic site) lyase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » apn-1 cDNA ORF clone
Gene Symbol | apn-1 |
Entrez Gene ID | 174291 |
Full Name | DNA-(apurinic or apyrimidinic site) lyase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_063286.5 | NP_495687.1 | DNA-(apurinic or apyrimidinic site) lyase |
NM_063286.6 | NP_495687.1 | DNA-(apurinic or apyrimidinic site) lyase |
Eremothecium gossypii | AGOS_ABL054C | NP_982893.1 |
Saccharomyces cerevisiae (baker's yeast) | APN1 | NP_012808.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100127659 | NP_001106474.1 |
Danio rerio (zebrafish) | LOC558198 | XP_686479.1 |
Caenorhabditis elegans (roundworm) | apn-1 | NP_495687.1 |
Kluyveromyces lactis | KLLA0C14256g | XP_452838.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_10609 | XP_003710706.1 |
Neurospora crassa | NCU10044 | XP_957961.2 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Base excision repair endonucleases APN-1 and EXO-3 function in the same pathway as DNA mismatch repair, to elicit DNA-directed toxicity in response to 5-fluorouracil.
Title: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.
Purified APN-1 displays AP endonuclease activity, 3'-diesterase activity, 3'- to 5'-exonuclease activity and the nucleotide incision repair activity.
Title: Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1.
results show that apurinic/apyrimidinic endonuclease 1/EXO-3, p53/CEP-1, and thioredoxin affect each other and that these interactions determine aging as well as neuronal structure and function
Title: Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
APN-1 is an important apurinic/apyrimidinc endonuclease for repair of misincorporated uracil.
Title: Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability.
Apn-1 expresses apurinic/apyrimidinic endonuclease in a Saccharomyces cerevisiae mutant.
Title: Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation.
The following apn-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the apn-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa337507 | |
Clone ID Related Accession (Same CDS sequence) | NM_063286.5 , NM_063286.6 | |
Accession Version | NM_063286.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | DNA-(apurinic or apyrimidinic site) lyase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Jun 26, 2012 this sequence version replaced NM_063286.4. COMPLETENESS: incomplete on both ends. |
1 | ATGGCTAACA AAAAAGTAAC ATTTAGAGAA GACGTAAAAT CACCGGCTAT CAGGAAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_495687.1 |
CDS | 1..1191 |
Translation |
Target ORF information:
Target ORF information:
|
NM_063286.5 |
1 | ATGGCTAACA AAAAAGTAAC ATTTAGAGAA GACGTAAAAT CACCGGCTAT CAGGAAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa337507 | |
Clone ID Related Accession (Same CDS sequence) | NM_063286.5 , NM_063286.6 | |
Accession Version | NM_063286.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | DNA-(apurinic or apyrimidinic site) lyase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Sep 4, 2019 this sequence version replaced NM_063286.5. COMPLETENESS: incomplete on the 5' end. |
1 | ATGGCTAACA AAAAAGTAAC ATTTAGAGAA GACGTAAAAT CACCGGCTAT CAGGAAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_495687.1 |
CDS | 1..1191 |
Translation |
Target ORF information:
Target ORF information:
|
NM_063286.6 |
1 | ATGGCTAACA AAAAAGTAAC ATTTAGAGAA GACGTAAAAT CACCGGCTAT CAGGAAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |