Gene Symbol | MOT2 |
Entrez Gene ID | 856799 |
Full Name | CCR4-NOT core ubiquitin-protein ligase subunit MOT2 |
Synonyms | NOT4,SIG1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MOT2 cDNA ORF clone
Gene Symbol | MOT2 |
Entrez Gene ID | 856799 |
Full Name | CCR4-NOT core ubiquitin-protein ligase subunit MOT2 |
Synonyms | NOT4,SIG1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001178959.3 | NP_010991.3 | CCR4-NOT core ubiquitin-protein ligase subunit MOT2 |
Eremothecium gossypii | AGOS_ADL064W | NP_984032.1 |
Kluyveromyces lactis | KLLA0C08041g | XP_452558.1 |
Saccharomyces cerevisiae (baker's yeast) | MOT2 | NP_010991.3 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome V.
Dietrich FS, Mulligan J, Hennessy K, Yelton MA, Allen E, Araujo R, Aviles E, Berno A, Brennan T, Carpenter J, Chen E, Cherry JM, Chung E, Duncan M, Guzman E, Hartzell G, Hunicke-Smith S, Hyman RW, Kayser A, Komp C, Lashkari D, Lew H, Lin D, Mosedale D, Davis RW
Nature387(6632 Suppl)78-81(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Not4 is required for global translational repression under nutritional limitations and especially for repression of mRNAs that cause transient ribosome stalling.
Title: Not4-dependent translational repression is important for cellular protein homeostasis in yeast.
Screening a variety of mutants involved in ubiquitin-mediated proteolysis demonstrated an important role for the nuclear ubiquitin ligase Not4 in Yap1 degradation. Not4 was found to bind to Yap1 in an oxidant-stimulated fashion
Title: Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4.
results identify a stress-induced proteolytic pathway regulating cyclin C that requires nuclear to cytoplasmic relocalization and Not4p-mediated ubiquitylation
Title: Oxidative-stress-induced nuclear to cytoplasmic relocalization is required for Not4-dependent cyclin C destruction.
Not4 is required for appropriate association of the Not5 subunit of the Ccr4-Not complex with polysomes and for ubiquitination of Rps7A.
Title: Presence of Not5 and ubiquitinated Rps7A in polysome fractions depends upon the Not4 E3 ligase.
results characterize Ecm29 as a proteasome chaperone whose appropriate interaction with the proteasome requires Not4
Title: Not4 E3 ligase contributes to proteasome assembly and functional integrity in part through Ecm29.
The following MOT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi05563 | |
Clone ID Related Accession (Same CDS sequence) | NM_001178959.3 | |
Accession Version | NM_001178959.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1764bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | CCR4-NOT core ubiquitin-protein ligase subunit MOT2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001137). On Jul 30, 2012 this sequence version replaced NM_001178959.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGATGAATC CACACGTTCA AGAAAATTTG CAAGCAATCC ACAACGCCTT AAGCAATTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010991.3 |
CDS | 1..1764 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001178959.3 |
1 | ATGATGAATC CACACGTTCA AGAAAATTTG CAAGCAATCC ACAACGCCTT AAGCAATTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome V. |
Life with 6000 genes. |