Gene Symbol | KIN28 |
Entrez Gene ID | 851450 |
Full Name | TFIIH complex serine/threonine-protein kinase subunit KIN28 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » KIN28 cDNA ORF clone
Gene Symbol | KIN28 |
Entrez Gene ID | 851450 |
Full Name | TFIIH complex serine/threonine-protein kinase subunit KIN28 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180167.1 | NP_010175.1 | TFIIH complex serine/threonine-protein kinase subunit KIN28 |
Pan troglodytes (chimpanzee) | CDK7 | XP_001160482.1 |
Canis lupus familiaris (dog) | CDK7 | XP_850424.1 |
Bos taurus (cattle) | CDK7 | NP_001069183.1 |
Gallus gallus (chicken) | CDK7 | XP_001234587.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_13401 | XP_003711393.1 |
CDK7 | XP_001092242.1 | |
Danio rerio (zebrafish) | cdk7 | NP_998126.2 |
Drosophila melanogaster (fruit fly) | Cdk7 | NP_511044.1 |
Homo sapiens (human) | CDK7 | NP_001790.1 |
Mus musculus (house mouse) | Cdk7 | NP_034004.2 |
Schizosaccharomyces pombe (fission yeast) | mcs6 | NP_596349.1 |
Neurospora crassa | NCU03659 | XP_960739.1 |
Rattus norvegicus (Norway rat) | Cdk7 | XP_006231929.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002646 | XP_312281.3 |
Caenorhabditis elegans (roundworm) | cdk-7 | NP_490952.2 |
Saccharomyces cerevisiae (baker's yeast) | KIN28 | NP_010175.1 |
Kluyveromyces lactis | KLLA0E14785g | XP_454616.1 |
Eremothecium gossypii | AGOS_ADL283W | NP_983813.1 |
Arabidopsis thaliana (thale cress) | CAK4 | NP_176847.1 |
Xenopus tropicalis (tropical clawed frog) | cdk7 | NP_001017219.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Inactivating Kin28 impacts promoter release to differing degrees and reveals a "checkpoint" during the transition to productive elongation, resulting in widespread mRNA stabilization.
Title: Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.
Kin28 has a role in the association of Mediator with promoters.
Title: Kin28 regulates the transient association of Mediator with core promoters.
These results identify an Spt5 phosphorylated C-terminal repeats-independent pathway of Paf1C recruitment requiring Kin28, Bur1, and the Spt5 phosphorylated C-terminal repeats-interaction domain of Cdc73.
Title: Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.
Study points strongly toward a minor role of TFIIH kinase in Pol II transcription, and a more significant role in mRNA capping in budding yeast.
Title: Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome.
Results implicate the TFIIH kinase in placing bivalent Ser5 and Ser7 marks early in gene transcription.
Title: TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.
The following KIN28 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KIN28 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00998 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180167.1 | |
Accession Version | NM_001180167.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | TFIIH complex serine/threonine-protein kinase subunit KIN28 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAAAGTGA ATATGGAGTA CACAAAGGAA AAGAAAGTTG GTGAGGGTAC TTATGCGGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010175.1 |
CDS | 1..921 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180167.1 |
1 | ATGAAAGTGA ATATGGAGTA CACAAAGGAA AAGAAAGTTG GTGAGGGTAC TTATGCGGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |