SHS1 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Important function of the CTEs of Cdc11 and Shs1 is optimizing recruitment of Bni5 and thereby ensuring efficient localization at the bud neck of Myo1, the type II myosin of the actomyosin contractile ring.
Title: The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae.

The sole portion of Shs1 essential for its function is predicted coiled-coil-forming segment in its C-terminal extension (CTE). CTE of Cdc11 shares this function. This role for the CTEs of Cdc11 and Shs1 is distinct from that of the CTEs of Cdc3 and Cdc12
Title: Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae.

Study shows that a direct interaction between the endoplasmic reticulum (ER) protein Scs2 and the septin Shs1 creates the diffusion barrier in yeast. Barrier formation requires Epo1, a novel ER-associated subunit of the polarisome that interacts with Scs2 and Shs1, encoded by the ORF YMR124W.
Title: Polarization of the endoplasmic reticulum by ER-septin tethering.

It was shown that Shs1 substitutes for Cdc11, resulting in octameric rods that do not polymerize into filaments but associate laterally, forming curved bundles that close into rings.
Title: Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation.

Septin Shs1 appears to have an important role in the response to DNA replication stress.
Title: An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth.