Gene Symbol | SEN1 |
Entrez Gene ID | 851150 |
Full Name | putative DNA/RNA helicase SEN1 |
Synonyms | CIK3,NRD2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » SEN1 cDNA ORF clone
Gene Symbol | SEN1 |
Entrez Gene ID | 851150 |
Full Name | putative DNA/RNA helicase SEN1 |
Synonyms | CIK3,NRD2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182318.3 | NP_013534.3 | putative DNA/RNA helicase SEN1 |
Kluyveromyces lactis | KLLA0B05555g | XP_451783.1 |
Eremothecium gossypii | AGOS_AER115W | NP_984975.2 |
Saccharomyces cerevisiae (baker's yeast) | SEN1 | NP_013534.3 |
Oryza sativa (rice) | Os06g0310200 | NP_001057481.2 |
Arabidopsis thaliana (thale cress) | MAA3 | NP_193292.3 |
Oryza sativa (rice) | Os03g0440200 | NP_001050457.2 |
Oryza sativa (rice) | Os04g0424200 | NP_001173937.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Johnston M, Hillier L, Riles L, Albermann K, Andr? B, Ansorge W, Benes V, Br?ckner M, Delius H, Dubois E, D?sterh?ft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, K?tter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD
Nature387(6632 Suppl)87-90(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The authors also show that subdomain 1C (the "prong") is an essential element for 5'-3' unwinding of RNA and for Sen1-mediated transcription termination in vitro.
Title: Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.
we identify new targets and functions of Sen1-dependent termination, including a role in repression of meiotic genes in vegetative cells. In combination with other recent whole-genome studies on termination of non-coding RNAs, our results provide promising directions for further investigation.
Title: Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome.
The helicase domain (HD) is sufficient to dissociate the elongation complex (EC) in vitro. Both full-length Sen1 and its HD can translocate along single-stranded RNA and DNA in the 5 to 3 direction.
Title: Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination.
DNA/RNA helicase Sen1 mutant causes modulation of protein-serine-threonine kinase TOR pathway and autophagy.
Title: Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae.
Data indicate that mutant of the RNA processing machinery (RNT1), and RNA/DNA helicase SEN1 mutants that are unable to interact with Rnt1p, exhibit a flocculation phenotype.
Title: Flocculation in Saccharomyces cerevisiae is regulated by RNA/DNA helicase Sen1p.
The following SEN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SEN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00743 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182318.3 | |
Accession Version | NM_001182318.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 6696bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | putative DNA/RNA helicase SEN1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001144). On Jul 30, 2012 this sequence version replaced NM_001182318.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAATTCCA ACAATCCTGA TAATAATAAT AGCAACAACA TTAATAATAA TAATAAGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013534.3 |
CDS | 1..6696 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAATTCCA ACAATCCTGA TAATAATAAT AGCAACAACA TTAATAATAA TAATAAGGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. |
Life with 6000 genes. |