Gene Symbol | MCM5 |
Entrez Gene ID | 850980 |
Full Name | MCM DNA helicase complex subunit MCM5 |
Synonyms | BOB1,CDC46 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MCM5 cDNA ORF clone
Gene Symbol | MCM5 |
Entrez Gene ID | 850980 |
Full Name | MCM DNA helicase complex subunit MCM5 |
Synonyms | BOB1,CDC46 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182161.1 | NP_013376.1 | MCM DNA helicase complex subunit MCM5 |
Homo sapiens (human) | MCM5 | NP_006730.2 |
Rattus norvegicus (Norway rat) | Mcm5 | NP_001099640.1 |
Oryza sativa (rice) | Os02g0797400 | NP_001048396.1 |
Pan troglodytes (chimpanzee) | MCM5 | XP_001156025.1 |
Canis lupus familiaris (dog) | MCM5 | XP_005626282.1 |
Caenorhabditis elegans (roundworm) | mcm-5 | NP_497858.1 |
Saccharomyces cerevisiae (baker's yeast) | MCM5 | NP_013376.1 |
Neurospora crassa | NCU01171 | XP_961537.1 |
Xenopus tropicalis (tropical clawed frog) | mcm5 | NP_001017327.2 |
Bos taurus (cattle) | MCM5 | NP_001068758.1 |
Mus musculus (house mouse) | Mcm5 | NP_032592.2 |
Gallus gallus (chicken) | MCM5 | NP_001006243.1 |
Drosophila melanogaster (fruit fly) | Mcm5 | NP_524308.2 |
Kluyveromyces lactis | KLLA0D09262g | XP_453475.1 |
Schizosaccharomyces pombe (fission yeast) | mcm5 | XP_001713071.1 |
Danio rerio (zebrafish) | mcm5 | NP_848523.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004408 | XP_313694.2 |
Eremothecium gossypii | AGOS_AGR276W | NP_986942.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08646 | XP_003711077.1 |
Arabidopsis thaliana (thale cress) | MCM5 | NP_178812.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Johnston M, Hillier L, Riles L, Albermann K, Andr? B, Ansorge W, Benes V, Br?ckner M, Delius H, Dubois E, D?sterh?ft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, K?tter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD
Nature387(6632 Suppl)87-90(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The Mcm ATPase active sites that flank Mcm2/5 (i.e. Mcm5/3 and 6/2) modulate the biochemical activities of the putative Mcm2/5 gate.
Title: The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.
DNA runs through a central channel in the double hexamer, and, once loaded, Mcm2-7 can slide passively along double-stranded DNA.
Title: Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.
Conclusions predict a structural discontinuity between Mcm2 and Mcm5 and demonstrate that in contrast to other hexameric helicases, the six Mcm2-7 active sites are functionally distinct.
Title: Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability.
Mcm5 protein has a positive role in origin binding, which requires coordination by all six Mcm2-7 subunits in the hexamer.
Title: Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae.
A domain-push model is proposed to explain the bypass activity of mutant proline62leucine BOB1, which has a major effect on helicase activity, but no significant impact on DNA binding or ATPase of Methanobacterium thermoautotrophicum MCM gene.
Title: Biochemical activities of the BOB1 mutant in Methanobacterium thermoautotrophicum MCM.
The following MCM5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCM5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00605 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182161.1 | |
Accession Version | NM_001182161.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2328bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | MCM DNA helicase complex subunit MCM5 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001144). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCATTTG ATAGACCGGA AATATACAGT GCTCCTGTTT TACAAGGAGA ATCTCCTAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013376.1 |
CDS | 1..2328 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001182161.1 |
1 | ATGTCATTTG ATAGACCGGA AATATACAGT GCTCCTGTTT TACAAGGAGA ATCTCCTAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. |
Life with 6000 genes. |