LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque
LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque

The purity of LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque is greater than 95% as determined by SEC-HPLC.

LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque

LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque

Anti-LILRB1 Antibody immobilized on CM5 Chip can bind LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque, hFc Tag with an affinity constant of 51.44 nM as determined in SPR assay (Biacore T200).

LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque

LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.
Z06448
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Product Introduction
Species Rhesus macaque
Protein Construction
LILRB1/CD85j/ILT2 (Ser17-His456)_x000D_
Accession # F7H3G7		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 74.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-90 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque
    • LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque

    The purity of LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque is greater than 95% as determined by SEC-HPLC.

  • LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque
    • LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque

    LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

  • LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque
    • LILRB1/CD85j/ILT2 HFc Chimera, Rhesus Macaque

    Anti-LILRB1 Antibody immobilized on CM5 Chip can bind LILRB1/CD85j/ILT2 hFc Chimera, Rhesus macaque, hFc Tag with an affinity constant of 51.44 nM as determined in SPR assay (Biacore T200).


Background
Target Background LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.
Synonyms ILT2; ILT-2; ILT2FLJ37515; LILRB1; LIR1; MIR7; CD85J; XXbac-BCX85G21.4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.