TRAIL R2/DR5/TNFRSF10B, His, Mouse
TRAIL R2/DR5/TNFRSF10B, His, Mouse

The purity of TRAIL R2/DR5/TNFRSF10B, His, Mouse is greater than 95% as determined by SEC-HPLC.

TRAIL R2/DR5/TNFRSF10B, His, Mouse

TRAIL R2/DR5/TNFRSF10B, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TRAIL R2/DR5/TNFRSF10B, His, Mouse

TRAIL R2/DR5/TNFRSF10B, His, Mouse on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.68 nM as determined in SPR assay (Biacore T200).

TRAIL R2/DR5/TNFRSF10B, His, Mouse

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Z06390
¥46,636.00

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Product Introduction
Species Mouse
Protein Construction
TRAIL R2/DR5/TNFRSF10B (Asn53-Lys180)_x000D_
Accession # Q9QZM4-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity TRAIL R2/DR5/TNFRSF10B, His, Mouse immobilized on CM5 Chip can bind Human TRAIL, No Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 15.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • TRAIL R2/DR5/TNFRSF10B, His, Mouse
    • TRAIL R2/DR5/TNFRSF10B, His, Mouse

    The purity of TRAIL R2/DR5/TNFRSF10B, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • TRAIL R2/DR5/TNFRSF10B, His, Mouse
    • TRAIL R2/DR5/TNFRSF10B, His, Mouse

    TRAIL R2/DR5/TNFRSF10B, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • TRAIL R2/DR5/TNFRSF10B, His, Mouse
    • TRAIL R2/DR5/TNFRSF10B, His, Mouse

    TRAIL R2/DR5/TNFRSF10B, His, Mouse on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.68 nM as determined in SPR assay (Biacore T200).


Background
Target Background DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Synonyms CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.