Siglec-5/CD170, His, Mouse
Siglec-5/CD170, His, Mouse

The purity of Siglec-5/CD170, His, Mouse is greater than 95% as determined by SEC-HPLC.

Siglec-5/CD170, His, Mouse

Siglec-5/CD170, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Siglec-5/CD170, His, Mouse

Interactions between endothelial selectins and the leukocyte counter-receptor PSGL1 mediates leukocyte recruitment to inflammation sites. PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures. Binding assays using soluble Siglec-5 variants (sSiglec-5/C4BP and sSiglec-5/Fc) revealed a dose- and calcium-dependent binding to PSGL1.
Z06353
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Product Introduction
Species Mouse
Protein Construction
Siglec-5/CD170 (Thr17-Leu439)_x000D_
Accession # Q920G3		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per ug by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 46.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Siglec-5/CD170, His, Mouse
    • Siglec-5/CD170, His, Mouse

    The purity of Siglec-5/CD170, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • Siglec-5/CD170, His, Mouse
    • Siglec-5/CD170, His, Mouse

    Siglec-5/CD170, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Interactions between endothelial selectins and the leukocyte counter-receptor PSGL1 mediates leukocyte recruitment to inflammation sites. PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures. Binding assays using soluble Siglec-5 variants (sSiglec-5/C4BP and sSiglec-5/Fc) revealed a dose- and calcium-dependent binding to PSGL1.
Synonyms CD170; CD33 antigen-like 2; CD33L2; OBBP2; Siglec5; SIGLEC5; OB-BP2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.