Serpin F1/PEDF, His, Mouse

Serpin F1/PEDF, His, Mouse

Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis.
Z06345
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Product Introduction
Species Mouse
Protein Construction
Serpin F1/PEDF (Gln20-Thr417)
Accession # P97298		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 45.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 48-55 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl (pH 8.0).
Concentration Verified by one or more methods from A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.

Background
Target Background Pigment epithelium-derived factor (PEDF) is an important antiangiogenic and antitumorigenic factor in a variety of cancer forms, including pancreatic cancer. PEDF is mainly secreted as a soluble monomeric glycoprotein. In human pancreatic cancer PEDF levels are decreased, both in the tissue and serum. The decrease is associated with increased tumor angiogenesis, fibrosis, inflammation, autophagy, occurrence of liver metastasis and worse prognosis.
Synonyms PEDF; EPC-1; Serpin F1; SERPINF1; PIG35

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.