RNF43 hFc Chimera, Mouse
RNF43 HFc Chimera, Mouse

Immobilized Mouse R spondin 1, His Tag at 2 μg /ml (100 μl/well) on the plate. Dose response curve for RNF43 hFc Chimera, Mouse, hFc Tag with the EC50 of 0.13 μg /ml determined by ELISA.

RNF43 HFc Chimera, Mouse

The purity of RNF43 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

RNF43 HFc Chimera, Mouse

RNF43 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

RNF43 hFc Chimera, Mouse

RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
Z06337
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Product Introduction
Species Mouse
Protein Construction
RNF43 (Gly24-Tyr197)
Accession # Q5NCP0		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 45.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 53-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • RNF43 HFc Chimera, Mouse
    • RNF43 HFc Chimera, Mouse

    Immobilized Mouse R spondin 1, His Tag at 2 μg /ml (100 μl/well) on the plate. Dose response curve for RNF43 hFc Chimera, Mouse, hFc Tag with the EC50 of 0.13 μg /ml determined by ELISA.

  • RNF43 HFc Chimera, Mouse
    • RNF43 HFc Chimera, Mouse

    The purity of RNF43 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

  • RNF43 HFc Chimera, Mouse
    • RNF43 HFc Chimera, Mouse

    RNF43 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
Synonyms E3 ubiquitin-protein ligase RNF43;RING finger protein 43;RING-type E3 ubiquitin transferase RNF43;Rnf43

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.