P-Selectin/CD62P, His, Mouse
P-Selectin/CD62P, His, Mouse

The purity of P-Selectin/CD62P, His, Mouse is greater than 95% as determined by SEC-HPLC.

P-Selectin/CD62P, His, Mouse

P-Selectin/CD62P, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

P-Selectin/CD62P, His, Mouse

P-selectin is critical in the progression of atherosclerosis as evidenced by knockout animal models where P-selectin knockout mice crossed with apoE deficient mice exhibit significantly reduced atherosclerosis and leukocyte recruitment in the plaque. A soluble form of P-selectin also exists, which may have pro-atherogenic and pro-thrombotic effects. Thus targeting of P-selectin remains a strong clinical candidate for developing novel therapeutic strategies in inflammatory diseases
Z06326
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Product Introduction
Species Mouse
Protein Construction
P-Selectin/CD62P (Trp42-Ala709)_x000D_
Accession # Q01102		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 81.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-130 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • P-Selectin/CD62P, His, Mouse
    • P-Selectin/CD62P, His, Mouse

    The purity of P-Selectin/CD62P, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • P-Selectin/CD62P, His, Mouse
    • P-Selectin/CD62P, His, Mouse

    P-Selectin/CD62P, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background P-selectin is critical in the progression of atherosclerosis as evidenced by knockout animal models where P-selectin knockout mice crossed with apoE deficient mice exhibit significantly reduced atherosclerosis and leukocyte recruitment in the plaque. A soluble form of P-selectin also exists, which may have pro-atherogenic and pro-thrombotic effects. Thus targeting of P-selectin remains a strong clinical candidate for developing novel therapeutic strategies in inflammatory diseases
Synonyms FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-Selectin; SELP; CD62P; CD62; LECAM3

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.