PCSK9, His, Mouse
PCSK9, His, Mouse

The purity of PCSK9, His, Mouse is greater than 95% as determined by SEC-HPLC.

PCSK9, His, Mouse

PCSK9, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PCSK9, His, Mouse

Human LDLR, His Tag immobilized on CM5 Chip can bind PCSK9, His, Mouse, His Tag with an affinity constant of 0.61 nM as determined in SPR assay (Biacore T200).

PCSK9, His, Mouse

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
Z06298
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Product Introduction
Species Mouse
Protein Construction
PCSK9 (Gln35-Gln694)_x000D_
Accession # Q80W65		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight the pro-form (59 kDa) and mature form (14 kDa)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-68 kDa (pro-form) and 15kDa (mature form) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM Tris, 150mM NaCL, 200mM L-Aginine (pH 8.2).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • PCSK9, His, Mouse
    • PCSK9, His, Mouse

    The purity of PCSK9, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • PCSK9, His, Mouse
    • PCSK9, His, Mouse

    PCSK9, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • PCSK9, His, Mouse
    • PCSK9, His, Mouse

    Human LDLR, His Tag immobilized on CM5 Chip can bind PCSK9, His, Mouse, His Tag with an affinity constant of 0.61 nM as determined in SPR assay (Biacore T200).


Background
Target Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
Synonyms PC9; PCSK9; FH3; HCHOLA3; LDLCQ1; NARC-1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.