MUC18/CD146, His, Mouse
MUC18/CD146, His, Mouse

The purity of MUC18/CD146, His, Mouse is greater than 95% as determined by SEC-HPLC.

MUC18/CD146, His, Mouse

MUC18/CD146, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MUC18/CD146, His, Mouse

METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.
Z06274
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Product Introduction
Species Mouse
Protein Construction
MUC18/CD146 (Val24-Val563)_x000D_
Accession # Q8R2Y2-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 60.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-95 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MUC18/CD146, His, Mouse
    • MUC18/CD146, His, Mouse

    The purity of MUC18/CD146, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • MUC18/CD146, His, Mouse
    • MUC18/CD146, His, Mouse

    MUC18/CD146, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells.
Synonyms Gicerin; CD146; MCAM; MUC18

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.