MDL-1/CLEC5A hFc Chimera, Mouse
MDL-1/CLEC5A HFc Chimera, Mouse

The purity of MDL-1/CLEC5A hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

MDL-1/CLEC5A HFc Chimera, Mouse

MDL-1/CLEC5A hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MDL-1/CLEC5A hFc Chimera, Mouse

In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor.MDL-1, like its mammalian orthologs, is an inhibitor of cell proliferation and growth that slows progression of an age-related pathology in C. elegans (uterine tumors). In addition, intestine-limited rescue of mdl-1 increased lifespan but not to wild type levels. Thus, mdl-1 likely acts both in the intestine and the germline to influence age-related mortality.
Z06264
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Product Introduction
Species Mouse
Protein Construction
hFc MDL-1/CLEC5A (Tyr26-Lys190)_x000D_
Accession # Q9R007-3
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 46.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 64-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MDL-1/CLEC5A HFc Chimera, Mouse
    • MDL-1/CLEC5A HFc Chimera, Mouse

    The purity of MDL-1/CLEC5A hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

  • MDL-1/CLEC5A HFc Chimera, Mouse
    • MDL-1/CLEC5A HFc Chimera, Mouse

    MDL-1/CLEC5A hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor.MDL-1, like its mammalian orthologs, is an inhibitor of cell proliferation and growth that slows progression of an age-related pathology in C. elegans (uterine tumors). In addition, intestine-limited rescue of mdl-1 increased lifespan but not to wild type levels. Thus, mdl-1 likely acts both in the intestine and the germline to influence age-related mortality.
Synonyms MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.