LILRB4/CD85k/ILT3, His, Mouse
LILRB4/CD85k/ILT3, His, Mouse

The purity of LILRB4/CD85k/ILT3, His, Mouse is greater than 95% as determined by SEC-HPLC.

LILRB4/CD85k/ILT3, His, Mouse

LILRB4/CD85k/ILT3, His, Mouse on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

LILRB4/CD85k/ILT3, His, Mouse

LILRB4/CD85k/ILT3, His, Mouse, His Tag immobilized on CM5 Chip can bind Mouse APOE, His Tag with an affinity constant of 5.08 nM as determined in SPR assay (Biacore T200).

LILRB4/CD85k/ILT3, His, Mouse

LILRB4,also known as CD85k and LIR-5, ILT3, is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation. Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).LILRB4 is receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Z06244
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Product Introduction
Species Mouse
Protein Construction
LILRB4/CD85k/ILT3 (Gly24-Lys238)_x000D_
Accession # Q64281-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 25.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-45 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • LILRB4/CD85k/ILT3, His, Mouse
    • LILRB4/CD85k/ILT3, His, Mouse

    The purity of LILRB4/CD85k/ILT3, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • LILRB4/CD85k/ILT3, His, Mouse
    • LILRB4/CD85k/ILT3, His, Mouse

    LILRB4/CD85k/ILT3, His, Mouse on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

  • LILRB4/CD85k/ILT3, His, Mouse
    • LILRB4/CD85k/ILT3, His, Mouse

    LILRB4/CD85k/ILT3, His, Mouse, His Tag immobilized on CM5 Chip can bind Mouse APOE, His Tag with an affinity constant of 5.08 nM as determined in SPR assay (Biacore T200).


Background
Target Background LILRB4,also known as CD85k and LIR-5, ILT3, is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation. Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).LILRB4 is receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Synonyms HM18; ILT3; ILT-3; LILRB4; LIR5; CD85K

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.