Loaded IL-22R alpha 1 hFc Chimera, Mouse, hFc Tag on ProA-Biosensor can bind Biotinylated Mouse IL-22, His-Avi Tag with an affinity constant of 13.50 nM as determined in BLI assay (Gator® Prime).
Immobilized Biotinylated Mouse IL-22, His Tag at 2 μg /ml (100 μl/well) on the streptavidin precoated plate(5 μg /ml). Dose response curve for IL-22R alpha 1 hFc Chimera, Mouse, hFc Tag with the EC50 of 15.2ng/ml determined by ELISA.
The purity of IL-22R alpha 1 hFc Chimera, Mouse 1 is greater than 95% as determined by SEC-HPLC.
IL-22R alpha 1 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
IL-22R alpha 1 hFc Chimera, Mouse
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3.
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