IFN alpha 1 hFc Chimera, Mouse
IFN Alpha 1 HFc Chimera, Mouse

IFN alpha 1 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IFN Alpha 1 HFc Chimera, Mouse

Human IFN alpha/beta R1, His Tag captured on CM5 Chip via anti-his antibody can bind IFN alpha 1 hFc Chimera, Mouse, hFc Tag with an affinity constant of 11.96 nM as determined in SPR assay (Biacore T200).

IFN alpha 1 hFc Chimera, Mouse

IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
Z06167
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Product Introduction
Species Mouse
Protein Construction
IFN alpha 1 (Cys24-Lys189)_x000D_
Accession # P01572		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IFN alpha/beta R1, His Tag captured on CM5 Chip via anti­his antibody can bind IFN alpha 1 hFc Chimera, Mouse in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 45.88 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IFN Alpha 1 HFc Chimera, Mouse
    • IFN Alpha 1 HFc Chimera, Mouse

    IFN alpha 1 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IFN Alpha 1 HFc Chimera, Mouse
    • IFN Alpha 1 HFc Chimera, Mouse

    Human IFN alpha/beta R1, His Tag captured on CM5 Chip via anti-his antibody can bind IFN alpha 1 hFc Chimera, Mouse, hFc Tag with an affinity constant of 11.96 nM as determined in SPR assay (Biacore T200).


Background
Target Background IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes.
Synonyms Interferon alpha-1/13;IFN-alpha-1/13;Interferon alpha-D;LeIF D; IFNalpha 1; IFN alpha1;IFNA1;IFN-alpha-1;Interferon alpha 1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.