ICOS/CD278 hFc Chimera, Mouse
ICOS/CD278 HFc Chimera, Mouse

The purity of ICOS/CD278 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

ICOS/CD278 HFc Chimera, Mouse

ICOS/CD278 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ICOS/CD278 HFc Chimera, Mouse

ICOS/CD278 hFc Chimera, Mouse on CM5 Chip via Protein A can bind Mouse B7-H2, His Tag with an affinity constant of 0.329 μM as determined in SPR assay

ICOS/CD278 hFc Chimera, Mouse

Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain.
Z06166
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Product Introduction
Species Mouse
Protein Construction
ICOS/CD278 (Glu21-Leu144)_x000D_
Accession # Q9WVS0		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 40.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • ICOS/CD278 HFc Chimera, Mouse
    • ICOS/CD278 HFc Chimera, Mouse

    The purity of ICOS/CD278 hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

  • ICOS/CD278 HFc Chimera, Mouse
    • ICOS/CD278 HFc Chimera, Mouse

    ICOS/CD278 hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • ICOS/CD278 HFc Chimera, Mouse
    • ICOS/CD278 HFc Chimera, Mouse

    ICOS/CD278 hFc Chimera, Mouse on CM5 Chip via Protein A can bind Mouse B7-H2, His Tag with an affinity constant of 0.329 μM as determined in SPR assay


Background
Target Background Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain.
Synonyms AILIM; CD278; CRP-1; CVID1; ICOS; MGC39850

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.