GPVI, His, Mouse
GPVI, His, Mouse

The purity of GPVI, His, Mouse is greater than 95% as determined by SEC-HPLC.

GPVI, His, Mouse

GPVI, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GPVI, His, Mouse

Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.
Z06157
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Product Introduction
Species Mouse
Protein Construction
GPVI (Gln22-Lys265)_x000D_
Accession # P0C191		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 28 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • GPVI, His, Mouse
    • GPVI, His, Mouse

    The purity of GPVI, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • GPVI, His, Mouse
    • GPVI, His, Mouse

    GPVI, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.
Synonyms GPVI; Gp6; Glycoprotein 6; MGC138168

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.