Glypican 1/GPC1, His, Mouse
Glypican 1/GPC1, His, Mouse

The purity of Glypican 1/GPC1, His, Mouse is greater than 95% as determined by SEC-HPLC.

Glypican 1/GPC1, His, Mouse

Glypican 1/GPC1, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Glypican 1/GPC1, His, Mouse

CAR-T cells targeting glypican-1 (GPC1)-specific human and murine CAR-T cells generated from our original anti-human/mouse GPC1 antibody showed strong antitumor effects in xenogeneic and syngeneic mouse models, respectively. Importantly, the murine CAR-T cells enhanced endogenous T cell responses against a non-GPC1 tumor antigen through the mechanism of antigen-spreading and showed synergistic antitumor effects with anti-PD-1 antibody without any adverse effects in syngeneic models.
Z06146
¥72,752.00

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Product Introduction
Species Mouse
Protein Construction
Glypican 1/GPC1 (Asp24-Ser529)_x000D_
Accession # Q9QZF2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 56.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM Tris,150mM NaCl (pH 7.5).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Glypican 1/GPC1, His, Mouse
    • Glypican 1/GPC1, His, Mouse

    The purity of Glypican 1/GPC1, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • Glypican 1/GPC1, His, Mouse
    • Glypican 1/GPC1, His, Mouse

    Glypican 1/GPC1, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background CAR-T cells targeting glypican-1 (GPC1)-specific human and murine CAR-T cells generated from our original anti-human/mouse GPC1 antibody showed strong antitumor effects in xenogeneic and syngeneic mouse models, respectively. Importantly, the murine CAR-T cells enhanced endogenous T cell responses against a non-GPC1 tumor antigen through the mechanism of antigen-spreading and showed synergistic antitumor effects with anti-PD-1 antibody without any adverse effects in syngeneic models.
Synonyms Glypican-1; FLJ38078; GPC1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.