GITR/TNFRSF18, His, Mouse
GITR/TNFRSF18, His, Mouse

GITR/TNFRSF18, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GITR/TNFRSF18, His, Mouse

GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Z06145
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Product Introduction
Species Mouse
Protein Construction
GITR/TNFRSF18 (Ser22-His153)_x000D_
Accession # Q8C4K3		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 15.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • GITR/TNFRSF18, His, Mouse
    • GITR/TNFRSF18, His, Mouse

    GITR/TNFRSF18, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Synonyms CD357; GITR; GITR-D; TNFRSF18; AITR

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.