FSTL3, His, Mouse
FSTL3, His, Mouse

Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 5-25 ng/mL in the presence of 7.5 ng/mL rhActivin A.

FSTL3, His, Mouse

Immobilized Human Activin A, No Tag at 0.2 μg/ml (100 μI/well) on the plate. Dose response curve for FSTL3, His, Mouse, His Tag with the EC50 of 20.1ng/ml determined by ELISA.

FSTL3, His, Mouse

The purity of FSTL3, His, Mouse is greater than 95% as determined by SEC-HPLC.

FSTL3, His, Mouse

FSTL3, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FSTL3, His, Mouse

FSTL3, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Human Activin A, No tag with an affinity constant of 53.09 pM as determined in SPR assay (Biacore T200).

FSTL3, His, Mouse

Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both human chronic kidney disease (CKD) and acute kidney dysfunction (AKD). Furthermore, mFSTL3 expression was analysed in insulin-sensitive tissues in a mouse model of CKD.
Z06131
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Product Introduction
Species Mouse
Protein Construction
FSTL3 (Val24-Val256)_x000D_
Accession # Q9EQC7		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 26 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • FSTL3, His, Mouse
    • FSTL3, His, Mouse

    Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 5-25 ng/mL in the presence of 7.5 ng/mL rhActivin A.

  • FSTL3, His, Mouse
    • FSTL3, His, Mouse

    Immobilized Human Activin A, No Tag at 0.2 μg/ml (100 μI/well) on the plate. Dose response curve for FSTL3, His, Mouse, His Tag with the EC50 of 20.1ng/ml determined by ELISA.

  • FSTL3, His, Mouse
    • FSTL3, His, Mouse

    The purity of FSTL3, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • FSTL3, His, Mouse
    • FSTL3, His, Mouse

    FSTL3, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • FSTL3, His, Mouse
    • FSTL3, His, Mouse

    FSTL3, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Human Activin A, No tag with an affinity constant of 53.09 pM as determined in SPR assay (Biacore T200).


Background
Target Background Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both human chronic kidney disease (CKD) and acute kidney dysfunction (AKD). Furthermore, mFSTL3 expression was analysed in insulin-sensitive tissues in a mouse model of CKD.
Synonyms FLRG; FLRGFSRP; Follistatin-like 3; FSTL3

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.