FcRn, His, Mouse
FcRn, His, Mouse

The purity of FcRn, His, Mouse is greater than 95% as determined by SEC-HPLC.

FcRn, His, Mouse

FcRn, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FcRn, His, Mouse

FcRn, His, Mouse on CM5 Chip via anti-his antibody can bind Trastuzumab with an affinity constant of 1.76 nM as determined in SPR assay (Biacore T200) (QC Test).

FcRn, His, Mouse

FcRn, His, Mouse on CM5 Chip can bind Mouse FcRn, His Tag with an affinity constant of 0.18 µM as determined in SPR assay (Biacore T200).

FcRn, His, Mouse

FcRn, His, Mouse, His Tag captured on CM5 Chip via Anti-His Antibody can bind Mouse IgG2a Fc, No Tag with an affinity constant of 2.72 nM as determined in SPR assay (Biacore T200).

FcRn, His, Mouse

FcRn, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Mouse IgG1 Fc, No Tag with an affinity constant of 15.09 nM as determined in SPR assay (Biacore T200).

FcRn, His, Mouse

The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells. FCGRT&B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Z06119
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Product Introduction
Species Mouse
Protein Construction
FcRn [Ser22-Ser297 (FCGRT)&Ile21-Met119 (B2M)]
Accession # Q61559(FCGRT)&P01887(B2M)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity FcRn, His, Mouse captured on CM5 Chip via anti­his antibody can bind Trastuzumab in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 32.1 kDa (FCGRT)&11.7 kDa (B2M)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-55 kDa (FCGRT)&14-15 kDa (B2M) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • FcRn, His, Mouse
    • FcRn, His, Mouse

    The purity of FcRn, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • FcRn, His, Mouse
    • FcRn, His, Mouse

    FcRn, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • FcRn, His, Mouse
    • FcRn, His, Mouse

    FcRn, His, Mouse on CM5 Chip via anti-his antibody can bind Trastuzumab with an affinity constant of 1.76 nM as determined in SPR assay (Biacore T200) (QC Test).

  • FcRn, His, Mouse
    • FcRn, His, Mouse

    FcRn, His, Mouse on CM5 Chip can bind Mouse FcRn, His Tag with an affinity constant of 0.18 µM as determined in SPR assay (Biacore T200).

  • FcRn, His, Mouse
    • FcRn, His, Mouse

    FcRn, His, Mouse, His Tag captured on CM5 Chip via Anti-His Antibody can bind Mouse IgG2a Fc, No Tag with an affinity constant of 2.72 nM as determined in SPR assay (Biacore T200).

  • FcRn, His, Mouse
    • FcRn, His, Mouse

    FcRn, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Mouse IgG1 Fc, No Tag with an affinity constant of 15.09 nM as determined in SPR assay (Biacore T200).


Background
Target Background The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells. FCGRT&B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Synonyms FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.