Fc gamma RIV/CD16-2, His, Mouse
Fc Gamma RIV/CD16-2, His, Mouse

The purity of Fc gamma RIV/CD16-2, His, Mouse is greater than 95% as determined by SEC-HPLC.

Fc Gamma RIV/CD16-2, His, Mouse

Fc gamma RIV/CD16-2, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Fc Gamma RIV/CD16-2, His, Mouse

Fc gamma RIV/CD16-2, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Anti-CD3 Antibody with an affinity constant of 146 nM as determined in SPR assay (Biacore T200).

Fc gamma RIV/CD16-2, His, Mouse

FcgammaRIV is a relatively new IgG Fc receptor (FcgammaR) that is reported to contribute to the pathogenesis of autoimmune diseases.FcgammaRIII and FcgammaRIV are each essential to trigger an FcRgamma-linker for activation of T-cell-dependent signal that drives C5a production in the Arthus reaction. A combined requirement for FcgammaRIII and FcgammaRIV in autoimmune injury, and identify the linker for activation of T cells adaptor as an integral component of linked FcgammaR and C5a anaphylatoxin receptor activation to generate inflammation.
Z06117
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Product Introduction
Species Mouse
Protein Construction
Fc gamma RIV/CD16-2 (Gly21-Gln203)
Accession # A0A0B4J1G0-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Fc gamma RIV/CD16-2, His, Mouse captured on CM5 Chip via anti­his antibody can bind Anti­CD3 Antibody in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 32-43 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Fc Gamma RIV/CD16-2, His, Mouse
    • Fc Gamma RIV/CD16-2, His, Mouse

    The purity of Fc gamma RIV/CD16-2, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • Fc Gamma RIV/CD16-2, His, Mouse
    • Fc Gamma RIV/CD16-2, His, Mouse

    Fc gamma RIV/CD16-2, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Fc Gamma RIV/CD16-2, His, Mouse
    • Fc Gamma RIV/CD16-2, His, Mouse

    Fc gamma RIV/CD16-2, His, Mouse, His Tag captured on CM5 Chip via anti-his antibody can bind Anti-CD3 Antibody with an affinity constant of 146 nM as determined in SPR assay (Biacore T200).


Background
Target Background FcgammaRIV is a relatively new IgG Fc receptor (FcgammaR) that is reported to contribute to the pathogenesis of autoimmune diseases.FcgammaRIII and FcgammaRIV are each essential to trigger an FcRgamma-linker for activation of T-cell-dependent signal that drives C5a production in the Arthus reaction. A combined requirement for FcgammaRIII and FcgammaRIV in autoimmune injury, and identify the linker for activation of T cells adaptor as an integral component of linked FcgammaR and C5a anaphylatoxin receptor activation to generate inflammation.
Synonyms CD16-2; FcgammaRIV; Fcgr4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.