Loaded Mouse TNFSF15, monomeric Fc Tag on ProA-Biosensor, can bind DR3/TNFRSF25, His, Mouse, His Tag with an affinity constant of 22.80 nM as determined in BLI assay (Gator).
Immobilized DR3/TNFRSF25, His, Mouse, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Mouse TNFSF15, His-Avi Tag with the EC50 of 4.9ng/ml determined by ELISA.
The purity of DR3/TNFRSF25, His, Mouse is greater than 95% as determined by SEC-HPLC.
DR3/TNFRSF25, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Mouse TNFSF15, hFc Tag captured on CM5 Chip via Protein A can bind DR3/TNFRSF25, His, Mouse, His Tag with an affinity constant of 4.56 nM as determined in SPR assay (Biacore T200).
DR3/TNFRSF25, His, Mouse
Death Receptor 3 (DR3), also known as TNFRSF25, TRAMP, LARD, or WSL-1, is a death-domain-containing TNF-family receptor that, like its closest paralog TNFR1, binds the adaptor molecule TRADD through its cytoplasmic death domain. TRADD recruitment endows DR3 with dual-signaling capability to activate NF−κB and MAP-kinase signaling or alternatively trigger caspase activation and programmed cell death.
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