Beta Klotho, His, Mouse

Beta Klotho, His, Mouse

Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.
Z06032
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Product Introduction
Species Mouse
Protein Construction
Beta Klotho (Phe53-Pro994)_x000D_
Accession # Q99N32-1		 His
N-term C-term
Purity > 90% as determined by Bis-Tris PAGE
> 90% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Beta Klotho, His, Mouse in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 109.91 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 120-130 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.
Synonyms betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; MGC142213;βKlotho; β-klotho; klotho β like; Klotho β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.