B7-H2/ICOSLG, His, Mouse
B7-H2/ICOSLG, His, Mouse

The purity of B7-H2/ICOSLG, His, Mouse is greater than 95% as determined by SEC-HPLC.

B7-H2/ICOSLG, His, Mouse

B7-H2/ICOSLG, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

B7-H2/ICOSLG, His, Mouse

B7-H2/ICOSLG, His, Mouse on CM5 Chip via Protein A can bind Mouse B7-H2, His Tag with an affinity constant of 0.329 μM as determined in SPR assay (Biacore T200).

B7-H2/ICOSLG, His, Mouse

B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
Z06022
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Product Introduction
Species Mouse
Protein Construction
B7-H2/ICOSLG (Glu47-Lys279)_x000D_
Accession # Q9JHJ8-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Mouse ICOS, hFc Tag captured on CM5 Chip via Protein A can bind B7-H2/ICOSLG, His, Mouse in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 27.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • B7-H2/ICOSLG, His, Mouse
    • B7-H2/ICOSLG, His, Mouse

    The purity of B7-H2/ICOSLG, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • B7-H2/ICOSLG, His, Mouse
    • B7-H2/ICOSLG, His, Mouse

    B7-H2/ICOSLG, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • B7-H2/ICOSLG, His, Mouse
    • B7-H2/ICOSLG, His, Mouse

    B7-H2/ICOSLG, His, Mouse on CM5 Chip via Protein A can bind Mouse B7-H2, His Tag with an affinity constant of 0.329 μM as determined in SPR assay (Biacore T200).


Background
Target Background B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
Synonyms CD275; B7H2; B7-H2; B7RP-1; GL50; ICOSL; ICOS-L; ICOSLG; B7RP1; LICOS; ICOS ligand; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.