AXL, His, Mouse
AXL, His, Mouse

The purity of AXL, His, Mouse is greater than 95% as determined by SEC-HPLC.

AXL, His, Mouse

AXL, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

AXL, His, Mouse

AXL, His, Mouse on CM5 Chip can bind Mouse GAS6, His Tag with an affinity constant of 15.62 nM as determined in SPR assay (Biacore T200).

AXL, His, Mouse

Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.
Z06018
¥31,712.00

Ask us a question
Product Introduction
Species Mouse
Protein Construction
AXL (His20-Trp445)_x000D_
Accession # NP_033491.2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity AXL, His, Mouse immobilized on CM5 Chip can bind Mouse GAS6, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 47.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-78 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • AXL, His, Mouse
    • AXL, His, Mouse

    The purity of AXL, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • AXL, His, Mouse
    • AXL, His, Mouse

    AXL, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • AXL, His, Mouse
    • AXL, His, Mouse

    AXL, His, Mouse on CM5 Chip can bind Mouse GAS6, His Tag with an affinity constant of 15.62 nM as determined in SPR assay (Biacore T200).


Background
Target Background Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers.
Synonyms Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; AI323647; EC 2.7.10; EC 2.7.10.1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.