AREG hFc Chimera, Mouse
AREG HFc Chimera, Mouse

The purity of AREG hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

AREG HFc Chimera, Mouse

AREG hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

AREG hFc Chimera, Mouse

Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.
Z06014
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Product Introduction
Species Mouse
Protein Construction
hFc AREG (Val100-Ala248)_x000D_
Accession # P31955
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 38.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • AREG HFc Chimera, Mouse
    • AREG HFc Chimera, Mouse

    The purity of AREG hFc Chimera, Mouse is greater than 95% as determined by SEC-HPLC.

  • AREG HFc Chimera, Mouse
    • AREG HFc Chimera, Mouse

    AREG hFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor.
Synonyms Amphiregulin; AR; SDGF; AREG; AREGB; CRDGF; MGC13647

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.