AMCase/CHIA, His, Mouse
AMCase/CHIA, His, Mouse

The purity of AMCase/CHIA, His, Mouse is greater than 95% as determined by SEC-HPLC.

AMCase/CHIA, His, Mouse

AMCase/CHIA, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

AMCase/CHIA, His, Mouse

Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. The expression of AMCase and CHIT-1 were differently modulated in HMMs at different stage of maturation.
Z05996
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Product Introduction
Species Mouse
Protein Construction
AMCase/CHIA (Tyr22-Pro473)_x000D_
Accession # Q91XA9		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 51 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 53-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • AMCase/CHIA, His, Mouse
    • AMCase/CHIA, His, Mouse

    The purity of AMCase/CHIA, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • AMCase/CHIA, His, Mouse
    • AMCase/CHIA, His, Mouse

    AMCase/CHIA, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. The expression of AMCase and CHIT-1 were differently modulated in HMMs at different stage of maturation.
Synonyms Acidic mammalian chitinase; AMCase; CHIA; CHIT2; EC 3.2.1.14; Chia1; YNL

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.