AGER, His, Mouse
AGER, His, Mouse

The purity of AGER, His, Mouse is greater than 95% as determined by SEC-HPLC.

AGER, His, Mouse

AGER, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

AGER, His, Mouse

The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NFκB, Akt, p38, and MAP kinases) that initiate and perpetuate an unfavorable proinflammatory state.
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Product Introduction
Species Mouse
Protein Construction
AGER (Gly23-Ala340)_x000D_
Accession # NP_031451.2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 34.85 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • AGER, His, Mouse
    • AGER, His, Mouse

    The purity of AGER, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • AGER, His, Mouse
    • AGER, His, Mouse

    AGER, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NFκB, Akt, p38, and MAP kinases) that initiate and perpetuate an unfavorable proinflammatory state.
Synonyms Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; RAGE

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.