Activin RIIA/ACVR2A, His, Mouse
Activin RIIA/ACVR2A, His, Mouse

The purity ofActivin RIIA/ACVR2A, His, Mouse is greater than 95% as determined by SEC-HPLC.

Activin RIIA/ACVR2A, His, Mouse

Activin RIIA/ACVR2A, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Activin RIIA/ACVR2A, His, Mouse

Activin RIIA/ACVR2A, His, Mouse on CM5 Chip via Anti-His Antibody can bind Human Activin A, No Tag with an affinity constant of 46.06 pM as determined in SPR assay (Biacore T200).

Activin RIIA/ACVR2A, His, Mouse

Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
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Product Introduction
Species Mouse
Protein Construction
Activin RIIA/ACVR2A (Ala20-Pro135)_x000D_
Accession # P27038		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Activin RIIA/ACVR2A, His, Mouse captured on CM5 Chip via Anti­His Antibody can bind Human Activin A, No Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 15.06 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Activin RIIA/ACVR2A, His, Mouse
    • Activin RIIA/ACVR2A, His, Mouse

    The purity ofActivin RIIA/ACVR2A, His, Mouse is greater than 95% as determined by SEC-HPLC.

  • Activin RIIA/ACVR2A, His, Mouse
    • Activin RIIA/ACVR2A, His, Mouse

    Activin RIIA/ACVR2A, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Activin RIIA/ACVR2A, His, Mouse
    • Activin RIIA/ACVR2A, His, Mouse

    Activin RIIA/ACVR2A, His, Mouse on CM5 Chip via Anti-His Antibody can bind Human Activin A, No Tag with an affinity constant of 46.06 pM as determined in SPR assay (Biacore T200).


Background
Target Background Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
Synonyms ACTR-IIA; ACTRIIA; ACVR2A; ACVR2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.