ACE2/ACEH, His, Mouse

ACE2/ACEH, His, Mouse

ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7.
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Product Introduction
Species Mouse
Protein Construction
ACE2/ACEH (Gln18-Thr740)_x000D_
Accession # Q8R0I0-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its ability to cleave a fluorogenic peptide substrate, Mca­YVADAPK(Dnp)­OH. The specific activity is >200 pmol/min/µg. Test result meets the standard.
Expression System HEK293
Theoretical Molecular Weight 84.57 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 85-105 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7.
Synonyms ACE-2; ACEH; ACE2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.